FB2024_03 , released June 25, 2024
Allele: Dmel\Fa2hKO1
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General Information
Symbol
Dmel\Fa2hKO1
Species
D. melanogaster
Name
FlyBase ID
FBal0400183
Feature type
allele
Associated gene
Dmel\Fa2h
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Li et al., 2024)
Mutagen
CRISPR/Cas9
(Li et al., 2024)
Progenitor genotype
Cytology
Description

CRISPR/Cas9 mediated non-homologous end joining (NHEJ) results in a deletion of +138 to +347bp and causes a frameshift in Fa2h.

(Li et al., 2024)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:7,449,422..7,449,631 [-]
Comment:

Deletion of +138 to +347 of Fa2h leads to a frameshift.

(Li et al., 2024)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      Fa2hKO1 has abnormal behavior | larval stage phenotype, non-enhanceable by Rh6G

      (Li et al., 2024)
      Suppressed by
      Statement
      Reference

      Fa2hKO1 has abnormal behavior | larval stage phenotype, suppressible | partially by Ir25a2

      (Li et al., 2024)

      Fa2hKO1 has abnormal behavior | larval stage phenotype, suppressible | partially by TrpA11

      (Li et al., 2024)
      NOT suppressed by
      Statement
      Reference

      Fa2hKO1 has abnormal behavior | larval stage phenotype, non-suppressible by Rh6G

      (Li et al., 2024)
      NOT Enhancer of
      Statement
      Reference

      Fa2hKO1 is a non-enhancer of abnormal behavior | larval stage phenotype of Rh6G

      (Li et al., 2024)

      Fa2hKO1 is a non-enhancer of abnormal behavior | larval stage phenotype of Ir25a2

      (Li et al., 2024)
      NOT Suppressor of
      Statement
      Reference

      Fa2hKO1 is a non-suppressor of abnormal behavior | larval stage phenotype of Rh6G

      (Li et al., 2024)

      Fa2hKO1 is a non-suppressor of abnormal behavior | larval stage phenotype of Ir25a2

      (Li et al., 2024)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Fa2hKO1
      fa2hKO1
      (Li et al., 2024)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)