FB2024_03 , released June 25, 2024
Allele: Dmel\Rh6G
Open Close
General Information
Symbol
Dmel\Rh6G
Species
D. melanogaster
Name
FlyBase ID
FBal0323531
Feature type
allele
Associated gene
Dmel\Rh6
Associated Insertion(s)
TI{GAL4}Rh6G
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-out gene targeting
(Sokabe et al., 2016)
Progenitor genotype
Associated Insertion(s)
TI{GAL4}Rh6G
Cytology
Description

The N-terminal 499bp of the Rh6 coding sequence has been replaced by sequence encoding a GAL4 driver followed by a w+mW.hs marker. This allows expression of GAL4 under the control of endogenous Rh6 regulatory sequences.

(Sokabe et al., 2016)
Allele components
Component
Use(s)
Inserted element
TI{GAL4}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Rh52 homozygous mutant late third instar (120 hr AEL) larvae show impaired temperature selection and unlike controls display no strong preference for cooler temperatures (18[o]C) in a temperature gradient. This effect does not appear to be due to developmental delay as the mutants develop with similar timing as controls, they also do not show any gross defects in the morphology of TrpA1 neurons, 18[o]C versus 28[o]C thermotaxis or crawling speed.

      (Sokabe et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      Rh6G has abnormal behavior | larval stage phenotype, non-enhanceable by Fa2hKO1

      (Li et al., 2024)
      NOT suppressed by
      Statement
      Reference

      Rh6G has abnormal behavior | larval stage phenotype, non-suppressible by Fa2hKO1

      (Li et al., 2024)
      NOT Enhancer of
      Statement
      Reference

      Rh6G is a non-enhancer of abnormal behavior | larval stage phenotype of Fa2hKO1

      (Li et al., 2024)
      NOT Suppressor of
      Statement
      Reference

      Rh6G is a non-suppressor of abnormal behavior | larval stage phenotype of Fa2hKO1

      (Li et al., 2024)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Rh61/Rh6G is rescued by Scer\GAL4Rh6-G/Rh6UAS.cVa

      (Sokabe et al., 2016)
      Comments

      Expression of Rh6Scer.UAS.cVa in under the control of Scer\GAL4Rh6-G in the Rh61/Rh6G transheterozygote larvae (using the intrinsic Gal4 driver in Rh6G) rescues the impaired thermotactic behavior characteristic for Rh61 mutants.

      (Sokabe et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rh6G
      rh6G
      (Li et al., 2024, Li et al., 2020, Sokabe et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)