FlyBase Allele Report: Dmel\hkb[351]

General Information

Symbol

Dmel\hkb³⁵¹

Species

D. melanogaster

Name

FlyBase ID

FBal0399449

Feature type

allele

Associated gene

Dmel\hkb

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Matthew et al., 2024)

Mutagen

CRISPR/Cas9

(Matthew et al., 2024)

Progenitor genotype

Cytology

Description

1bp deletion within hkb that results in a frameshift after only 11 residues.

(Matthew et al., 2024)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:4,346,469..4,346,469 [-]

Comment:

A 1bp deletion in hkb in codon 12 leads to a frameshift and early translation termination.

(Matthew et al., 2024)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

hkb³⁵¹ has increased occurrence of cell division | embryonic stage phenotype, non-enhanceable by Scer\GAL4^fkh.PH/BacA\p35^UAS.cHa

(Matthew et al., 2024)

Suppressed by

Statement

Reference

hkb³⁵¹ has increased occurrence of cell division | embryonic stage phenotype, suppressible by Scer\GAL4^fkh.PH/fzr^UAS.cSa

(Matthew et al., 2024)

hkb³⁵¹ has increased cell death | embryonic stage phenotype, suppressible | partially by Scer\GAL4^fkh.PH/fzr^UAS.cSa

(Matthew et al., 2024)

hkb³⁵¹ has decreased size | embryonic stage phenotype, suppressible | partially by Scer\GAL4^fkh.PH/fzr^UAS.cSa

(Matthew et al., 2024)

hkb³⁵¹ has increased cell death | embryonic stage phenotype, suppressible by CycE^AR95

(Matthew et al., 2024)

hkb³⁵¹ has increased occurrence of cell division | embryonic stage phenotype, suppressible by Cdk1^B47

(Matthew et al., 2024)

hkb³⁵¹ has increased cell death | embryonic stage phenotype, suppressible by Cdk1^B47

(Matthew et al., 2024)

hkb³⁵¹ has increased occurrence of cell division | embryonic stage phenotype, suppressible by CycE^AR95

(Matthew et al., 2024)

hkb³⁵¹ has decreased size | embryonic stage phenotype, suppressible by Scer\GAL4^fkh.PH/BacA\p35^UAS.cHa

(Matthew et al., 2024)

hkb³⁵¹ has increased cell death | embryonic stage phenotype, suppressible by Scer\GAL4^fkh.PH/BacA\p35^UAS.cHa

(Matthew et al., 2024)

hkb³⁵¹ has decreased cell number | embryonic stage phenotype, suppressible by Scer\GAL4^fkh.PH/BacA\p35^UAS.cHa

(Matthew et al., 2024)

hkb³⁵¹ has decreased size | embryonic stage phenotype, suppressible by Scer\GAL4^fkh.PH/fzr^UAS.cSa/BacA\p35^UAS.cHa

(Matthew et al., 2024)

hkb³⁵¹ has increased occurrence of cell division | embryonic stage phenotype, suppressible by CycD¹

(Matthew et al., 2024)

hkb³⁵¹ has increased occurrence of cell division | embryonic stage phenotype, suppressible by Scer\GAL4^fkh.PH/CycE^GL00511

(Matthew et al., 2024)

hkb³⁵¹ has increased cell death | embryonic stage phenotype, suppressible by Scer\GAL4^fkh.PH/CycE^GL00511

(Matthew et al., 2024)

hkb³⁵¹ has decreased size | embryonic stage phenotype, suppressible | partially by Scer\GAL4^fkh.PH/CycE^GL00511

(Matthew et al., 2024)

hkb³⁵¹ has increased occurrence of cell division | embryonic stage phenotype, suppressible by Cdk1^HMS01531/Scer\GAL4^fkh.PH

(Matthew et al., 2024)

hkb³⁵¹ has increased cell death | embryonic stage phenotype, suppressible by Cdk1^HMS01531/Scer\GAL4^fkh.PH

(Matthew et al., 2024)

hkb³⁵¹ has decreased size | embryonic stage phenotype, suppressible | partially by Cdk1^HMS01531/Scer\GAL4^fkh.PH

(Matthew et al., 2024)

NOT suppressed by

Statement

Reference

hkb³⁵¹ has increased occurrence of cell division | embryonic stage phenotype, non-suppressible by Scer\GAL4^fkh.PH/BacA\p35^UAS.cHa

(Matthew et al., 2024)

Other

Statement

Reference

Cdk1^HMS01531, Scer\GAL4^fkh.PH, hkb³⁵¹ has visible | embryonic stage phenotype

(Matthew et al., 2024)

BacA\p35^UAS.cHa, Scer\GAL4^fkh.PH, hkb³⁵¹ has visible | embryonic stage phenotype

(Matthew et al., 2024)

BacA\p35^UAS.cHa, Scer\GAL4^fkh.PH, fzr^UAS.cSa, hkb³⁵¹ has visible | embryonic stage phenotype

(Matthew et al., 2024)

Scer\GAL4^fkh.PH, fzr^UAS.cSa, hkb³⁵¹ has visible | embryonic stage phenotype

(Matthew et al., 2024)

CycE^GL00511, Scer\GAL4^fkh.PH, hkb³⁵¹ has visible | embryonic stage phenotype

(Matthew et al., 2024)

Phenotype Manifest In

Suppressed by

Statement

Reference

hkb³⁵¹ has embryonic/larval salivary gland | embryonic stage phenotype, suppressible by CycE^AR95

(Matthew et al., 2024)

hkb³⁵¹ has embryonic/larval salivary gland | embryonic stage phenotype, suppressible by CycD¹

(Matthew et al., 2024)

hkb³⁵¹ has embryonic/larval salivary gland | embryonic stage phenotype, suppressible by Scer\GAL4^fkh.PH/CycE^GL00511

(Matthew et al., 2024)

hkb³⁵¹ has embryonic/larval salivary gland | embryonic stage phenotype, suppressible by Cdk1^HMS01531/Scer\GAL4^fkh.PH

(Matthew et al., 2024)

hkb³⁵¹ has embryonic/larval salivary gland | embryonic stage phenotype, suppressible | partially by Scer\GAL4^fkh.PH/fzr^UAS.cSa

(Matthew et al., 2024)

hkb³⁵¹ has embryonic/larval salivary gland | embryonic stage phenotype, suppressible by Cdk1^B47

(Matthew et al., 2024)

hkb³⁵¹ has embryonic/larval salivary gland | embryonic stage phenotype, suppressible by Scer\GAL4^fkh.PH/BacA\p35^UAS.cHa

(Matthew et al., 2024)

hkb³⁵¹ has embryonic/larval salivary gland | embryonic stage phenotype, suppressible by Scer\GAL4^fkh.PH/fzr^UAS.cSa/BacA\p35^UAS.cHa

(Matthew et al., 2024)

NOT suppressed by

Statement

Reference

hkb³⁵¹ has embryonic/larval salivary gland | embryonic stage phenotype, non-suppressible by CycA^C8LR1

(Matthew et al., 2024)

Other

Statement

Reference

Cdk1^HMS01531, Scer\GAL4^fkh.PH, hkb³⁵¹ has embryo phenotype

(Matthew et al., 2024)

BacA\p35^UAS.cHa, Scer\GAL4^fkh.PH, hkb³⁵¹ has embryo phenotype

(Matthew et al., 2024)

BacA\p35^UAS.cHa, Scer\GAL4^fkh.PH, fzr^UAS.cSa, hkb³⁵¹ has embryo phenotype

(Matthew et al., 2024)

Scer\GAL4^fkh.PH, fzr^UAS.cSa, hkb³⁵¹ has embryo phenotype

(Matthew et al., 2024)

CycE^GL00511, Scer\GAL4^fkh.PH, hkb³⁵¹ has embryo phenotype

(Matthew et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

hkb³⁵¹ is rescued by Scer\GAL4^fkh.PH/hkb^UAS.cMa

(Matthew et al., 2024)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

hkb³⁵¹

(Matthew et al., 2024)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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