FlyBase Allele Report: Dmel\yki[3SA.lexAop.sfGFP]

General Information

Symbol

Dmel\yki^{3SA.lexAop.sfGFP}

Species

D. melanogaster

Name

FlyBase ID

FBal0392913

Feature type

allele

Associated gene

Dmel\yki

Associated Insertion(s)

Carried in Construct

P{lexAop-yki.S3A.sfGFP}

Key Links

Transgenic product class

missense_variant

(Saavedra et al., 2023)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Saavedra et al., 2023)

Mutagen

in vitro construct

(Saavedra et al., 2023)

Progenitor genotype

Carried in construct

P{lexAop-yki.S3A.sfGFP}

Cytology

Description

13xlexAop2 regulatory sequences drive expression of a mutated form of yki (contains the S111A, S168A, S250A mutations), tagged with sfGFP.

(Saavedra et al., 2023)

Allele components

Component

Use(s)

Regulatory region(s)

lexAop

binary expression system - regulatory region

Encoded product / tool

yki

Tagged with

sfGFP

green fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of intestinal cancer

CEA

(Xu et al., 2024, Saavedra et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of intestinal cancer

is ameliorated by Akt^{ΔPH.UAS.Tag:Myr(Unk)}

(Saavedra et al., 2023)

is ameliorated by REPTOR^NIG.13624R

(Saavedra et al., 2023)

is ameliorated by Pvr^HMS01662

(Xu et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult somatic muscle cell, with Ecol\lexA^SJH-1

(Saavedra et al., 2023)

dorsal longitudinal indirect flight muscle, with Ecol\lexA^SJH-1

(Saavedra et al., 2023)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Ecol\lexA^SJH-1, REPTOR^NIG.13624R, Scer\GAL4^Mef2.PU, yki^{3SA.lexAop.sfGFP} has short lived phenotype

(Saavedra et al., 2023)

Phenotype Manifest In

Suppressed by

Statement

Reference

Ecol\lexA^SJH-1, yki^{3SA.lexAop.sfGFP} has adult somatic muscle cell phenotype, suppressible | partially by Akt^{ΔPH.UAS.Tag:Myr(Unk)}/Scer\GAL4^Mef2.PU

(Saavedra et al., 2023)

Ecol\lexA^SJH-1, yki^{3SA.lexAop.sfGFP} has dorsal longitudinal indirect flight muscle phenotype, suppressible | partially by Akt^{ΔPH.UAS.Tag:Myr(Unk)}/Scer\GAL4^Mef2.PU

(Saavedra et al., 2023)

Ecol\lexA^SJH-1, yki^{3SA.lexAop.sfGFP} has adult somatic muscle cell phenotype, suppressible | partially by whd^HMS00040/Scer\GAL4^Mef2.PU

(Saavedra et al., 2023)

Ecol\lexA^SJH-1, yki^{3SA.lexAop.sfGFP} has dorsal longitudinal indirect flight muscle phenotype, suppressible | partially by whd^HMS00040/Scer\GAL4^Mef2.PU

(Saavedra et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

yki^{3SA.lexAop.sfGFP}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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