FB2024_03 , released June 25, 2024
Allele: Dmel\borr::IncenpΔC.ΔHP1.UASp.RR
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General Information
Symbol
Dmel\borr::IncenpΔC.ΔHP1.UASp.RR
Species
D. melanogaster
Name
FlyBase ID
FBal0367894
Feature type
allele
Associated gene
borr::Incenp
Associated Insertion(s)
Carried in Construct
P{UASp-borr::Incenp.ΔC.ΔHP1.RR}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Wang et al., 2021)
Progenitor genotype
Carried in construct
P{UASp-borr::Incenp.ΔC.ΔHP1.RR}
Cytology
Description

UASp regulatory sequences drive expression of a fusion protein in which the N-terminal 46 amino acids of Incenp (the Borealin-Survivin domain) have been replaced with borr coding sequence that lacks the C-terminal domain (only borr amino acids 1-17 are present). In addition, sequence encoding the two putative Su(var)205 protein interaction sites has been deleted from the Incenp sequence. Eight silent mutations have also been introduced into the region corresponding to Incenp amino acids 437-441; this renders the construct resistant to RNAi mediated by P{TRiP.GL00279}.

(Wang et al., 2021)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
borr::Incenp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      borr::IncenpΔC.ΔHP1.UASp.RR
      Name Synonyms
      Secondary FlyBase IDs
        References (1)