UASt regulatory sequences drive expression of Hsap\MATR3 carrying the disease-associated F115C amino acid substitution.
Expression of Hsap\MATR3F115C.UAS.Tag:FLAG under the control of Scer\GAL4αTub84B.Switch.PK (in combination with RU486 feeding) leads to a reduction in the number of synaptic NMJ boutons in third instar larvae and a reduction in the climbing ability of adults.
Expression of Hsap\MATR3F115C.UAS.Tag:FLAG under the control of Scer\GAL4Mhc.PU leads to a progressive climbing speed reduction in adults. It also leads to smaller dorsal longitudinal muscles with enlarged gaps between muscle fibers in adults.
Hsap\MATR3F115C.UAS.Tag:FLAG, Scer\GAL4αTub84B.Switch.PK has short lived | RU486 conditional phenotype, suppressible | partially by rumpKK102889, Scer\GAL4αTub84B.Switch.PK
Hsap\MATR3F115C.UAS.Tag:FLAG, Scer\GAL4αTub84B.PL has lethal phenotype, non-suppressible by rumpKK102889, Scer\GAL4αTub84B.PL