A four-nucleotide deletion at 118 nucleotides downstream of a start codon, resulting in a frameshift and incorporation of ectopic amino acids followed by a premature stop codon at 145 nucleotides downstream of a start codon. This mutation resembles a variant in the orthologous Hsap\YPEL3 gene that is associated with a rare human disorder with peripheral neurological conditions including hypotonia and areflexia mutations.
A 4nt deletion 118nt from the start codon resulting in a frame shift after codon 39 causing a premature stop after 9 out-of-frame codons.
YpelT1-8 homozygotes show reduced nociceptive behavior to AITC (decreased larval rolling). There is reduced physical contact between nociceptors and their postsynaptic neurons, and reduced synaptic transmission between them (reduced neuronal activity in BASIN-4 neurons but not in their presynaptic nociceptors).
YpelT1-8 is rescued by YpelUAS.cKa/Scer\GAL4ppk.PG
