FB2024_03 , released June 25, 2024
Allele: Dmel\Rsph4aΔ409
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General Information
Symbol
Dmel\Rsph4aΔ409
Species
D. melanogaster
Name
FlyBase ID
FBal0352288
Feature type
allele
Associated gene
Dmel\Rsph4a
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Wang et al., 2019)
Progenitor genotype
Cytology
Description

A 409 bp DNA fragment of Rsph4a is deleted.

(Wang et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Rsph4aΔ409 males show spermatogenesis defects: testes are completely devoid of mature sperms in the seminal vesicle; cystic bulges are smaller; the individualization complex is asynchronous, as illustrated by individual cysts exhibiting both pre- and post-individualized spermatids; and there is increased apoptosis; in all cases, the axoneme lacks the central paired microtubules.

      (Wang et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rsph4aΔ409
      drsph4aΔ409
      (Wang et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)