FB2024_03 , released June 25, 2024
Allele: Dmel\Eaat2n1
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General Information
Symbol
Dmel\Eaat2n1
Species
D. melanogaster
Name
FlyBase ID
FBal0349053
Feature type
allele
Associated gene
Dmel\Eaat2
Associated Insertion(s)
PBac{RB5.WH5}Eaat2n1
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Stahl et al., 2018)
Mutagen
FLPase
(Stahl et al., 2018)
Progenitor genotype
PBac{WH}Eaat2f06549
(Stahl et al., 2018)
PBac{RB}Eaat2e04636
(Stahl et al., 2018)
Associated Insertion(s)
PBac{RB5.WH5}Eaat2n1
Cytology
Description

5.797kb deletion that removes the entire Eaat2 coding region. Generated by FLP-mediated recombination between the PBac{RB}Eaat2e04636 and PBac{WH}Eaat2f06549 insertions; a hybrid PBac{RB5.WH5} element remains at the site of the deletion.

(Stahl et al., 2018)
Allele components
Component
Use(s)
Inserted element
PBac{RB5.WH5}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2L:737,921..744,188 [-]
Comment:

5.797kb deletion that removes the entire Eaat2 coding region. Generated by Scer\FLP1-mediated recombination between the PBac{RB}Eaat2e04636 and PBac{WH}Eaat2f06549 insertions; a hybrid PBac{RB5.WH5} element of ~6.1kb remains at the site of the deletion.

(Stahl et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eaat2n1 adults show normal lifespan, feeding time and female fecundity.

      Eaat2n1 adults sleep significantly more only during daytime and show significantly longer sleep bouts during both daytime and nighttime, as compared to controls. Their sleep bout numbers, awaking activity and sleep recovery after mechanical sleep deprivation is comparable to controls. In agreement with the sleep defects, these adults show a decrease in metabolic rate during daytime, as compared to controls.

      (Stahl et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Eaat2n1
      (Stahl et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)