FlyBase Allele Report: Dmel\Sema5c[K175]

General Information

Symbol

Dmel\Sema5c^K175

Species

D. melanogaster

Name

FlyBase ID

FBal0347471

Feature type

allele

Associated gene

Dmel\Sema5c

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell migration | oogenesis

(Williams and Horne-Badovinac, 2024, Stedden et al., 2019)

abnormal size | oogenesis

(Stedden et al., 2019)

abnormal size | oogenesis (with Df(3L)BSC840)

(Stedden et al., 2019)

viable

(Stedden et al., 2019)

visible | oogenesis

(Stedden et al., 2019)

visible | oogenesis (with Df(3L)BSC840)

(Stedden et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

In Sema5c^K175 homozygous females, egg chambers and eggs are rounder (reduced length/width aspect ratio) than in controls. Follicular epithelium migration is severely reduced (and often delayed) in stage 3-7 egg chambers; stress fibers are initially misaligned (stage 2-7), but become mostly indistinguishable from controls in stage 7 egg chambers.

In Sema5c^K175 follicle cell clones, basal protrusions appear correctly located but are more mis-oriented than in controls.

Sema5c^K175/Df(3L)BSC840 transheterozygous females also produce rounder eggs.

(Stedden et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Sema5c^K175 has abnormal cell migration | oogenesis phenotype, enhanceable by Scer\GAL4^NP1624/Lar^HMS02186

(Williams and Horne-Badovinac, 2024)

NOT Enhanced by

Statement

Reference

Sema5c^K175 has abnormal size | oogenesis phenotype, non-enhanceable by kug^N103-2/kug[+]

(Stedden et al., 2019)

Sema5c^K175 has visible | oogenesis phenotype, non-enhanceable by kug^N103-2/kug[+]

(Stedden et al., 2019)

Suppressed by

Statement

Reference

Sema5c^K175 has visible | oogenesis phenotype, suppressible | partially by Lar[+]/Lar^13.2

(Stedden et al., 2019)

Sema5c^K175 has abnormal size | oogenesis phenotype, suppressible by Lar^bola2/Lar[+]

(Stedden et al., 2019)

Sema5c^K175 has visible | oogenesis phenotype, suppressible by Lar^bola2/Lar[+]

(Stedden et al., 2019)

Sema5c^K175 has abnormal size | oogenesis phenotype, suppressible | partially by Lar^bola1/Lar[+]

(Stedden et al., 2019)

Sema5c^K175 has visible | oogenesis phenotype, suppressible | partially by Lar^bola1/Lar[+]

(Stedden et al., 2019)

Sema5c^K175 has abnormal size | oogenesis phenotype, suppressible | partially by Lar[+]/Lar^13.2

(Stedden et al., 2019)

NOT suppressed by

Statement

Reference

Sema5c^K175 has abnormal cell migration | oogenesis phenotype, non-suppressible by Lar^bola2/Lar[+]

(Stedden et al., 2019)

Enhancer of

Statement

Reference

Sema5c^K175 is an enhancer of abnormal cell migration | oogenesis phenotype of Lar^HMS02186, Scer\GAL4^NP1624

(Williams and Horne-Badovinac, 2024)

Sema5c^K175/Sema5c^K175 is an enhancer of visible | oogenesis | dominant phenotype of kug^N103-2

(Stedden et al., 2019)

Sema5c^K175/Sema5c^K175 is an enhancer of abnormal size | oogenesis | dominant phenotype of kug^N103-2

(Stedden et al., 2019)

Phenotype Manifest In

Enhanced by

Statement

Reference

Sema5c^K175 has follicle cell phenotype, enhanceable by Scer\GAL4^NP1624/Lar^HMS02186

(Williams and Horne-Badovinac, 2024)

NOT Enhanced by

Statement

Reference

Sema5c^K175 has egg phenotype, non-enhanceable by kug^N103-2/kug[+]

(Stedden et al., 2019)

Suppressed by

Statement

Reference

Sema5c^K175 has follicle cell phenotype, suppressible | partially by Lar^bola2/Lar[+]

(Stedden et al., 2019)

Sema5c^K175 has egg phenotype, suppressible | partially by Lar^bola1/Lar[+]

(Stedden et al., 2019)

Sema5c^K175 has egg phenotype, suppressible | partially by Lar[+]/Lar^13.2

(Stedden et al., 2019)

Sema5c^K175 has egg phenotype, suppressible by Lar^bola2/Lar[+]

(Stedden et al., 2019)

Sema5c^K175 has stress fiber | oogenesis phenotype, suppressible | partially by Lar^bola2/Lar[+]

(Stedden et al., 2019)

NOT suppressed by

Statement

Reference

Sema5c^K175 has follicle cell phenotype, non-suppressible | partially by Lar^bola2/Lar[+]

(Stedden et al., 2019)

Enhancer of

Statement

Reference

Sema5c^K175 is an enhancer of follicle cell phenotype of Lar^HMS02186, Scer\GAL4^NP1624

(Williams and Horne-Badovinac, 2024)

Sema5c^K175/Sema5c^K175 is an enhancer of egg phenotype of kug^N103-2

(Stedden et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Sema-5c^K175

(Stedden et al., 2019)

Sema5c^K175

(Williams and Horne-Badovinac, 2024)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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