FB2024_03 , released June 25, 2024
Allele: Dmel\Mhc+t24.1
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General Information
Symbol
Dmel\Mhc+t24.1
Species
D. melanogaster
Name
FlyBase ID
FBal0346211
Feature type
allele
Associated gene
Dmel\Mhc
Associated Insertion(s)
Carried in Construct
P{Mhc+24.1}
Also Known As
pWMhc2
Key Links
Transgenic product class
genomic_DNA
(Swank et al., 2000)
wild_type
(Swank et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Swank et al., 2000)
wild_type
(Swank et al., 2000)
Mutagen
in vitro construct
(Swank et al., 2003, Swank et al., 2000)
Progenitor genotype
Carried in construct
P{Mhc+24.1}
Cytology
Description

24.1kb genomic sequence that encompasses the Mhc transcription unit, extending from approximately 850bp upstream of the transcription start site to 1.3kb 3' of the second polyadenylation site within exon 19.

(Swank et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
Mhc
Encoded product / tool
Mhc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      MhcR249Q/+, Mhc10/Mhc10 individuals do nor show any obvious defects in DLM fibers.

      (Bell et al., 2019)

      Both Mhc+t24.1 hetero- and homo-zygosity in a Mhc10 background is viable and adults can fly. In the Mhc+t24.1, Mhc10 double homozygosity condition, pupal and adult indirect flight muscles show regularly packed myofibrils, with six thin filaments around each thick filament and well-formed sarcomeres.

      (Rao et al., 2019)

      Flies expressing Mhc+t12.4 are able to jump 1.5-fold farther than Mhc10 mutants.

      Relaxed tension of tergal depressor of the trochanter (TDT) muscle expressing Mhc+t12.4 is very low, especially compared to the indirect flight muscles. Net active tension is approximately 30-fold higher than passive tension in Mhc+t12.4 flies, whereas all myosins tested in the indirect flight muscles exhibit passive tension levels almost equal to net active tension. TDT expressing Mhc+t12.4 exhibit a very steep tension-pCa curve.

      (Eldred et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Mhc+t24.1 rescues Mhc10

      (Bell et al., 2019)

      Mhc+t24.1 rescues Mhc10

      (Eldred et al., 2010)

      Mhc+t24.1 rescues Mhc1/Mhc[+]

      (Swank et al., 2000)
      Comments

      Mhc10 mutants expressing Mhc+t12.4 display normal jumping ability and ultrastructure.

      (Eldred et al., 2010)

      The addition of Mhc+t24.1 rescues flight levels in a Mhc1 heterozygous background to wild-type levels.

      (Swank et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mhc+t12.4
      Mhc+t24.1
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0147781
      • FBal0260722
      References (24)