FB2024_03 , released June 25, 2024
Allele: Dmel\nenyadel
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General Information
Symbol
Dmel\nenyadel
Species
D. melanogaster
Name
FlyBase ID
FBal0345528
Feature type
allele
Associated gene
Dmel\nenya
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
FLPase
(Lake et al., 2019)
Progenitor genotype
PBac{WH}minof04927
(Lake et al., 2019)
PBac{WH}minof01088
(Lake et al., 2019)
Cytology
Description

Deletion of the entire nenya gene.

(Lake et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:27,927,118..27,928,590 [-]
Comment:

Scer\FRT-mediated recombination between the two progenitor insertions, PBac{WH}minof04927 and PBac{WH}minof01088 has resulted in the deletion of the genomic sequence between them.

(Lake et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      nenyadel/nenyadel, naryaJJ6/naryaJJ6 females show frequent meiotic chromosome segregation errors, as assessed by X-chromosome non-disjunction; in agreement, meiotic recombination fails to initiate in early pachytene cysts, with few if any DSBs being detected (γH2AV foci). The X-chromosome non-disjunction is fully rescued by the expression of naryaUASp.GFP under the control of Scer\GAL4VP16.nos.UTR. nenyadel/nenyadel, naryaJJ6/+ females, naryaGFP/naryaGFP, nenyadel/+ females and naryaGFP/naryaGFP, nenyadel/nenyadel females do not show significant meiotic chromosome segregation errors, as assessed by X-chromosome non-disjunction.

      (Lake et al., 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      This deletion of nenya may also disrupt the mino gene because nenya is located in the first intron of mino.

      (Gershoni et al., 2023)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      nenyadel
      (Gershoni et al., 2023, Lake et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)