FB2024_03 , released June 25, 2024
Allele: Dmel\LkrGAL4::VP16
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General Information
Symbol
Dmel\LkrGAL4::VP16
Species
D. melanogaster
Name
FlyBase ID
FBal0344970
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Associated Insertion(s)
Cytology
Description

GAL4::VP16 and a Disc\RFP3xP3.cUa marker flanked by loxP sites is inserted in Lkr upstream of the ATG (-111bp to -106bp, relative to start site).

Allele components
Component
Use(s)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

LkrGAL4::VP16 homozygous and heterozygous mutant adults survive significantly longer under starvation or desiccation stress, compared to controls; they have significantly reduced locomotor activity and metabolic rate (carbon dioxide consumption), compared to controls; they have significantly reduced long-term, but not short-term food intake, compared to controls, with a stronger effect in homozygotes; LkrGAL4::VP16 homozygous adults have significantly increased cell body size in the abdominal LK neurons; homozygotes, but not heterozygotes, have increased proboscis extensions in response to sucrose, compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
LkrGAL4::VP16
Name Synonyms
Secondary FlyBase IDs
    References (1)