UASt regulates expression of Hsap\UBQLN2 bearing the clinically validated ALS-associated P497H mutation.
The expression from two copies of Hsap\UBQLN2P497H.UAS under the control of Scer\GAL4GMR.PF leads to an age-dependent loss of interommatidial bristles, hyperpigmented eye patches and photoreceptor neuron defects, including fused and missing rhabdomeres; expression from one copy does not have obvious eye phenotypes.
The expression of Hsap\UBQLN2P497H.UAS under the control of Scer\GAL4elav.PLu leads to adults showing a significant decrease in climbing ability; third instar larval neuromuscular junctions show a significant increase in the number of mature boutons, a significant decrease in bouton size, but no significant change in the number of satellite boutons.
Df(2L)BSC37, Hsap\UBQLN2P497H.UAS, Scer\GAL4GMR.PU has melanotic necrosis phenotype
Df(2R)ED2219, Hsap\UBQLN2P497H.UAS, Scer\GAL4GMR.PU has visible phenotype
Df(2R)ED2747, Hsap\UBQLN2P497H.UAS, Scer\GAL4GMR.PU has visible phenotype
Hsap\UBQLN2P497H.UAS, Rab5JF03335, Scer\GAL4GMR.PU has melanotic necrosis phenotype
Hsap\UBQLN2P497H.UAS, Rab5JF03335, Scer\GAL4GMR.PU has abnormal eye color phenotype
Df(2L)BSC37, Hsap\UBQLN2P497H.UAS, Scer\GAL4GMR.PU has abnormal eye color phenotype
Df(2L)ED441, Hsap\UBQLN2P497H.UAS, Scer\GAL4GMR.PU has visible phenotype
Df(2R)Exel6064, Hsap\UBQLN2P497H.UAS, Scer\GAL4GMR.PU has melanotic necrosis phenotype
Df(2R)Exel6064, Hsap\UBQLN2P497H.UAS, Scer\GAL4GMR.PU has abnormal eye color phenotype
Df(2L)ED250, Hsap\UBQLN2P497H.UAS, Scer\GAL4GMR.PU has abnormal eye color phenotype
Df(2L)BSC37, Hsap\UBQLN2P497H.UAS, Scer\GAL4GMR.PU has eye phenotype
Df(2R)ED2219, Hsap\UBQLN2P497H.UAS, Scer\GAL4GMR.PU has eye phenotype
Df(2R)ED2747, Hsap\UBQLN2P497H.UAS, Scer\GAL4GMR.PU has eye phenotype
Hsap\UBQLN2P497H.UAS, Rab5JF03335, Scer\GAL4GMR.PU has eye phenotype
Df(2L)ED441, Hsap\UBQLN2P497H.UAS, Scer\GAL4GMR.PU has eye phenotype
Df(2R)Exel6064, Hsap\UBQLN2P497H.UAS, Scer\GAL4GMR.PU has eye phenotype
Df(2L)ED250, Hsap\UBQLN2P497H.UAS, Scer\GAL4GMR.PU has eye phenotype