FlyBase Allele Report: Dmel\futsch[CR13]

General Information

Symbol

Dmel\futsch^CR13

Species

D. melanogaster

Name

FlyBase ID

FBal0341190

Feature type

allele

Associated gene

Dmel\futsch

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Migh et al., 2018)

Mutagen

CRISPR/Cas9

(Migh et al., 2018)

Progenitor genotype

Cytology

Description

A ~300bp deletion in the first coding exon of futsch.

(Migh et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:1,414,289..1,414,635 [+]

Comment:

347 bp deletion that removes most of the first coding exon of futsch.

(Mihaly, 2019.1.22)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval neuromuscular junction | larval stage

(Migh et al., 2018)

larval LL1 motor neuron | larval stage

(Migh et al., 2018)

NMJ bouton | larval stage

(Migh et al., 2018)

Detailed Description

Statement

Reference

Larval neuromuscular junctions at muscles 4 in futsch^CR13 mutants display apparently fewer and smaller synaptic boutons, but normal presynaptic microtubules organization, as compared to controls.

(Migh et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

futsch^CR13 has embryonic/larval neuromuscular junction | larval stage phenotype, enhanceable by DAAM^Ex68

(Migh et al., 2018)

futsch^CR13 has NMJ bouton | larval stage phenotype, enhanceable by DAAM^Ex68

(Migh et al., 2018)

futsch^CR13 has larval LL1 motor neuron | larval stage phenotype, enhanceable by DAAM^Ex68

(Migh et al., 2018)

Enhancer of

Statement

Reference

futsch^CR13 is an enhancer of embryonic/larval neuromuscular junction | larval stage phenotype of DAAM^Ex68

(Migh et al., 2018)

futsch^CR13 is an enhancer of larval LL1 motor neuron | larval stage phenotype of DAAM^Ex68

(Migh et al., 2018)

NOT Enhancer of

Statement

Reference

futsch^CR13 is a non-enhancer of NMJ bouton | larval stage phenotype of DAAM^Ex68

(Migh et al., 2018)

Other

Statement

Reference

DAAM^Ex68, futsch^CR13 has microtubule | larval stage phenotype

(Migh et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

The larval muscle 4 neuromuscular junction in DAAM^Ex68, futsch^CR13 double mutants show fragmented presynaptic microtubules bundles, as compared to controls.

(Migh et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

futsch^CR13

(Mihaly, 2019.1.22, Migh et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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