FB2024_03 , released June 25, 2024
Allele: Hsap\CCN2UAS.cYa
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General Information
Symbol
Hsap\CCN2UAS.cYa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Yang
FlyBase ID
FBal0338079
Feature type
allele
Associated gene
Hsap\CCN2
Associated Insertion(s)
Carried in Construct
P{UAS-hCTGF.Y}
Key Links
Transgenic product class
cDNA
(Yang et al., 2017)
wild_type
(Yang et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Yang et al., 2017)
wild_type
(Yang et al., 2017)
Mutagen
in vitro construct
(Yang et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-hCTGF.Y}
Cytology
Description

UAS regulatory sequences drive expression of a Hsap\CTGF cDNA.

(Yang et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\CCN2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Alzheimer's disease
      modeled by Hsap\APPAβ42.UAS.cBa
      (Yang et al., 2017)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\CTGFUAS.cYa under the control of Scer\GAL4GMR.PU does not lead to any photoreceptor degeneration and ommatidial disorganization in the adult eye.

      (Yang et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The Hsap\APP protein accumulations and neuronal loss in adult brain along with the age-progressive memory loss and climbing ability deficit characteristic for adult flies expressing Hsap\APPAβ42.Scer\UAS.cBa under the control of Scer\GAL4elav.PU can be at least partially rescued by co-expression of Hsap\CTGFUAS.cYa.

      Similarly, the progressive photoreceptor degeneration in the adult eye observed upon Scer\GAL4GMR.PU-driven expression of Hsap\APPAβ42.Scer\UAS.cBa can be significantly suppressed either by co-expression of Hsap\CTGFUAS.cYa or by combination with Hsap\CTGFrepo.PY (expressed in glial cells) but not by co-expression of Hsap\CTGFUAS.cYa combined with either Mmp1JF01336 or Mmp2JF01337.

      (Yang et al., 2017)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Hsap\CCN2UAS.cYa
      Hsap\CTGFScer\UAS.cYa
      Hsap\CTGFUAS.cYa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Yang
      Secondary FlyBase IDs
        References (1)