UAS regulatory sequences drive expression of Hsap\VPS35 cDNA with an amino acid replacement (pathogenic D620N human mutation).
The expression of Hsap\VPS35D620N.Scer\UAS.cIa under the control of Scer\GAL4ple.PF does not significantly affect the spontaneous synaptic activity on adult dendritic arborizing neurons, as compared to controls.
Scer\GAL4da.G32/Hsap\VPS35D620N.UAS.cIa is a non-suppressor of lethal - all die before end of prepupal stage phenotype of Vps35MH20/Vps351
The expression of Hsap\VPS35D620N.Scer\UAS.cIa under the control of Scer\GAL4da.G32 does not suppress the prepupal lethality of Vps351/Vps35MH20 transheterozygotes.