FB2024_03 , released June 25, 2024
Allele: Dmel\dhdtC34S
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General Information
Symbol
Dmel\dhdtC34S
Species
D. melanogaster
Name
FlyBase ID
FBal0327525
Feature type
allele
Associated gene
Dmel\dhd
Associated Insertion(s)
Carried in Construct
PBac{dhdtC34S}
Key Links
Transgenic product class
missense_variant
(Tirmarche et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Tirmarche et al., 2016)
Mutagen
in vitro construct
(Tirmarche et al., 2016)
Progenitor genotype
Carried in construct
PBac{dhdtC34S}
Cytology
Description

4303bp genomic fragment containing the a mutated version of the dhd coding sequence (replacement of the second cysteine residue in the WCGPCK catalytic motif), along with upstream (1932bp) and downstream (2047bp) regions.

(Tirmarche et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
dhd
Encoded product / tool
dhd
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      dhdtC34S fails to rescue dhdJ5

      (Tirmarche et al., 2016)
      Comments

      dhdtC34S fails to rescue the female sterility of dhdJ5 homozygotes. dhdtC34S also fails to rescue the male pronucleus chromatin defects observed upon fertilization of eggs laid by dhdJ5 homozygous females.

      (Tirmarche et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      dhdtC34S
      Name Synonyms
      Secondary FlyBase IDs
        References (1)