FB2024_03 , released June 25, 2024
Allele: Dmel\enΔ1.5
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General Information
Symbol
Dmel\enΔ1.5
Species
D. melanogaster
Name
FlyBase ID
FBal0327354
Feature type
allele
Associated gene
Dmel\en
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    A 1.5kb deletion upstream of the en promoter that removes the two known en Polycomb group response elements (PREs).

    (De et al., 2016)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        About 45% of enΔ1.5 mutants show defects in fusion of left and right abdominal dorsal hemisegments.

        (De et al., 2016)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        enΔ1.5 has visible | adult stage phenotype, enhanceable by inv[+]/invΔ24

        (De et al., 2016)
        NOT Enhanced by
        Statement
        Reference

        enΔ1.5 has visible | adult stage phenotype, non-enhanceable by Df(2R)Δ110

        (De et al., 2016)
        Other
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        enΔ1.5 has adult abdomen phenotype, enhanceable by inv[+]/invΔ24

        (De et al., 2016)
        NOT Enhanced by
        Statement
        Reference

        enΔ1.5 has adult abdomen phenotype, non-enhanceable by Df(2R)Δ110

        (De et al., 2016)
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        enΔ1.5, inven80 double homozygous adults (males and females) display a cuticle fusion defect in the abdominal midline.

        (De et al., 2019)

        enΔ1.5 homozygous mutants carrying one copy of invΔ24 show wing posture defects (held-out wings), extra wing vein material at the posterior crossvein and the penetrance of abdominal hemisegments fusion defects observed in enΔ1.5-only mutants is increased to 100%. In contrast, the penetrance of the hemisegment fusion defects is not much enhanced by combination with Df(2R)Δ110, but all of these flies display various wing vein defects.

        enΔ1.5 heterozygotes homozygous for invΔ24 show fully penetrant hemisegment fusion phenotype but only about 14% percent of them also display aberrant wing posture. The full double homozygotes all hold-out their wings in addition to the fusion defects and also exhibit an ectopic wing vein material phenotype of similar severity and penetrance as the enΔ1.5,invΔ24/enΔ1.5,+ flies.

        enΔ1.5,invΔ24/Df(2R)Δ110 adults show fully penetrant wing posture, wing vein as well as hemisegment fusion defects.

        (De et al., 2016)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        enΔ1.5
        (De et al., 2019, De et al., 2016)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)