FlyBase Allele Report: Hsap\TARDBP[UAS.cIb]

General Information

Symbol

Hsap\TARDBP^UAS.cIb

Species

H. sapiens

Name

Saccharomyces cerevisiae UAS construct b of Ishiguro

FlyBase ID

FBal0327172

Feature type

allele

Associated gene

Hsap\TARDBP

Associated Insertion(s)

Carried in Construct

P{UAS-hTARDBP.Ib}

Also Known As

UAS-TDP-43^WT

Key Links

Transgenic product class

wild_type

(Ishiguro et al., 2017)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Ishiguro et al., 2017)

Mutagen

in vitro construct

(Ishiguro et al., 2017)

Progenitor genotype

Carried in construct

P{UAS-hTARDBP.Ib}

Cytology

Description

UAS regulatory sequences drive expression of full-length Hsap\TARDBP.

(Ishiguro et al., 2017)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\TARDBP

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of amyotrophic lateral sclerosis

CEA

(Ishiguro et al., 2017)

model of amyotrophic lateral sclerosis type 10

CEA

(Godfrey et al., 2023)

CEC

(Nitta et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of amyotrophic lateral sclerosis

is ameliorated by Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

is ameliorated by Zzzz\UGGAA^22.UAS

(Ishiguro et al., 2017)

ameliorates spinocerebellar ataxia type 31

modeled by Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

modeled by Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult Kenyon cell | decreased number, with Hsap\RELA^AD.VT036268, Scer\GAL4^DBD.R21B06

(Godfrey et al., 2023)

eye, with Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

lobe system of adult mushroom body, with Hsap\RELA^AD.VT036268, Scer\GAL4^DBD.R21B06

(Godfrey et al., 2023)

retina | adult stage, with Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Detailed Description

Statement

Reference

The expression of Hsap\TARDBP^Scer\UAS.cIb under the control of Scer\GAL4^GMR.PS leads to a mild rough eye phenotype, including the thinning of the retina, as compared to controls.

(Ishiguro et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS has visible | adult stage phenotype, suppressible | partially by Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS has abnormal size | adult stage phenotype, suppressible | partially by Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS has visible | adult stage phenotype, suppressible | partially by Zzzz\UGGAA^W.UAS, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS has abnormal size | adult stage phenotype, suppressible | partially by Zzzz\UGGAA^W.UAS, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

NOT suppressed by

Statement

Reference

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS, Zzzz\UGGAA^S.UAS has visible | adult stage phenotype, non-suppressible by caz^KK107486, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS, Zzzz\UGGAA^S.UAS has abnormal size | adult stage phenotype, non-suppressible by caz^KK107486, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS, Zzzz\UGGAA^S.UAS has visible | adult stage phenotype, non-suppressible by Hrb87F^KK108162, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS, Zzzz\UGGAA^S.UAS has abnormal size | adult stage phenotype, non-suppressible by Hrb87F^KK108162, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS, Zzzz\UGGAA^S.UAS has visible | adult stage phenotype, non-suppressible by Hrb98DE^GD14939, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS, Zzzz\UGGAA^S.UAS has abnormal size | adult stage phenotype, non-suppressible by Hrb98DE^GD14939, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

NOT Enhancer of

Statement

Reference

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS is a non-enhancer of abnormal eye color phenotype of Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS

(Fujino et al., 2023)

Suppressor of

Statement

Reference

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PS, Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PS, Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS is a suppressor | partially of abnormal eye color phenotype of Scer\GAL4^GMR.PS, Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PS, Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PS, Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS is a suppressor | partially of abnormal eye color phenotype of Scer\GAL4^GMR.PS, Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

NOT Suppressor of

Statement

Reference

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS is a non-suppressor of abnormal eye color phenotype of Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS

(Fujino et al., 2023)

Other

Statement

Reference

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS, Zzzz\GGGGCC^89.UAS has lethal phenotype

(Fujino et al., 2023)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS has eye phenotype, suppressible | partially by Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS has retina | adult stage phenotype, suppressible | partially by Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS has eye phenotype, suppressible | partially by Zzzz\UGGAA^W.UAS, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS has retina | adult stage phenotype, suppressible | partially by Zzzz\UGGAA^W.UAS, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

NOT suppressed by

Statement

Reference

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS, Zzzz\UGGAA^S.UAS has eye | adult stage phenotype, non-suppressible by caz^KK107486, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS, Zzzz\UGGAA^S.UAS has eye | adult stage phenotype, non-suppressible by Hrb87F^KK108162, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS, Zzzz\UGGAA^S.UAS has eye | adult stage phenotype, non-suppressible by Hrb98DE^GD14939, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

NOT Enhancer of

Statement

Reference

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS

(Fujino et al., 2023)

Suppressor of

Statement

Reference

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS is a suppressor | partially of eye | adult stage phenotype of Scer\GAL4^GMR.PS, Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS is a suppressor | partially of eye | adult stage phenotype of Scer\GAL4^GMR.PS, Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

NOT Suppressor of

Statement

Reference

Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS

(Fujino et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The co-expression of Hsap\TARDBP^Scer\UAS.cIb decreases the severity of the eye defects resulting from the expression of either Zzzz\UGGAA^W.Scer\UAS or Zzzz\UGGAA^S.Scer\UAS, under the control of Scer\GAL4^GMR.PS (i.e. reduced size, loss of pigmentation, defective morphology and ommatidial abnormalities); these partial suppressions of the eye phenotypes are not furthered by the additional co-expression of caz^KK107486, Hrb87F^KK108162 or Hrb98DE^GD14939.

The retina thinning resulting from the expression of Hsap\TARDBP^Scer\UAS.cIb under the control of Scer\GAL4^GMR.PS is partially suppressed by the co-expression of either Zzzz\UGGAA^22.Scer\UAS or Zzzz\UGGAA^W.Scer\UAS.

(Ishiguro et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\TARDBP^Scer\UAS.cIb

Hsap\TARDBP^UAS.cIb

Name Synonyms

Saccharomyces cerevisiae UAS construct b of Ishiguro

Secondary FlyBase IDs

References (4)

Report Sections

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