FB2024_03 , released June 25, 2024
Allele: Dmel\Rgk1UAS.B
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General Information
Symbol
Dmel\Rgk1UAS.B
Species
D. melanogaster
Name
FlyBase ID
FBal0326523
Feature type
allele
Associated gene
Dmel\Rgk1
Associated Insertion(s)
Carried in Construct
P{UAS-Rgk1.B}
Key Links
Transgenic product class
wild_type
(Murakami et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Murakami et al., 2017)
Mutagen
in vitro construct
(Murakami et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-Rgk1.B}
Cytology
Description

UASt regulatory sequences drive expression of the RB isoform of Rgk1.

(Murakami et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Rgk1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Rgk1Scer\UAS.B under the control of Scer\GAL4ey-OK107, but not Scer\GAL4c739 or Scer\GAL4elav-C155, leads to a significant increase in intermediate-term olfactory memory (2h after conditioning), assessed by olfactory aversive conditioning assays, as compared to controls; expression under the control of control of Scer\GAL4ey-OK107, however, does not lead to significant changes in short-term olfactory memory (5min after conditioning) performance, as compared to controls.

      (Murakami et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4ey-OK107/Rgk1UAS.B rescues Rgk1Δ

      (Murakami et al., 2017)

      Scer\GAL4elav-C155/Rgk1UAS.B rescues Rgk1Δ

      (Murakami et al., 2017)
      Partially rescues

      Rgk1UAS.B/Scer\GAL4c739 partially rescues Rgk1Δ

      (Murakami et al., 2017)
      Comments

      The expression of Rgk1Scer\UAS.B, under the control of Scer\GAL4ey-OK107 alone, or in combination with Gal80[ts] to transiently express only for 3 days during adulthood, rescues the intermediate-term olfactory memory (2h after conditioning) defects observed in Rgk1Δ homozygous adults, and even leads to significant increases in intermediate-term memory performance as compared to controls; expression under the control of Scer\GAL4c739 alone or Scer\GAL4elav-C155 alone also partially and fully rescues, respectively, the intermediate-term olfactory memory defects of Rgk1Δ homozygous adults.

      (Murakami et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rgk1Scer\UAS.B
      Rgk1UAS.B
      Name Synonyms
      Secondary FlyBase IDs
        References (1)