FB2024_03 , released June 25, 2024
Allele: Dmel\Mst77FΔ2
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General Information
Symbol
Dmel\Mst77FΔ2
Species
D. melanogaster
Name
FlyBase ID
FBal0326353
Feature type
allele
Associated gene
Dmel\Mst77F
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Kimura and Loppin, 2016)
Mutagen
CRISPR/Cas9
(Kimura and Loppin, 2016)
Progenitor genotype
Cytology
Description

1bp deletion within the Mst77F coding sequence.

(Kimura and Loppin, 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:20,817,850..20,817,850 [-]
Comment:

1bp deletion within the Mst77F coding sequence at amino acid 10.

(Kimura and Loppin, 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mst77FΔ1 homozygotes are male sterile; Mst77FΔ1/Mst77FΔ2 or Mst77FΔ2/Mst77FΔ3 transheterozygous males produce very rare progeny.

      Mst77FΔ2 homozygotes and Mst77FΔ1/Mst77FΔ2 transheterozygotes present defective spermatid individualization, as compared to controls: spermatids are in disorganized bundles, retain the individualization complexes and present defects in nuclei morphology and chromatin compaction, as compared to controls.

      (Kimura and Loppin, 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Mst77FΔ3

      (Kimura and Loppin, 2016)
      Partially rescued by

      Mst77FΔ1/Mst77FΔ2 is partially rescued by Mst77F+tg

      (Kimura and Loppin, 2016)

      Mst77FΔ1/Mst77FΔ2 is partially rescued by Mst77FmRFP1

      (Kimura and Loppin, 2016)
      Not rescued by

      Mst77FΔ1/Mst77FΔ2 is not rescued by Mst77FEGFP

      (Kimura and Loppin, 2016)
      Comments

      Mst77FΔ2 fails to complement either Mst77FΔ1 or Mst77F[Δ3].

      The male semi-sterility of Mst77FΔ1/Mst77FΔ2 heterozygotes is partially rescued by one copy of either Mst77F+tg or Mst77FT:Disc\RFP-mRFP, but not Mst77FT:Avic\GFP-EGFP.

      (Kimura and Loppin, 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mst77FΔ2
      (Kimura and Loppin, 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)