Amino acid replacement: D406V.
A19279345T
D406V | rib-PB; D406V | rib-PA; D406V | rib-PC
D406V
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
germline cell | embryonic stage (with rib1)
gonad | embryonic stage (with rib1)
gonad | embryonic stage (with rib55.25)
rib35.14/rib55.25 and rib35.14/rib1 transheterozygous embryos, but not rib35.14 heterozygotes, display a significant increase in defects in the fusion together and compaction of primordial germ cells and somatic gonadal precursor cells, as compared to controls.
rib35.14/rib55.25 transheterozygous embryos also display a significant increase in the number of extragonadal primordial germ cells, but no obvious defects in the development of the visceral mesoderm, as compared to controls.
rib35.14/rib55.25 has gonad | embryonic stage phenotype, enhanceable by lola[+]/lola22.05
rib35.14/rib55.25 has gonadal sheath proper primordium phenotype, enhanceable by lola[+]/lola22.05
rib35.14/rib55.25 has germline cell | embryonic stage phenotype, enhanceable by lola[+]/lola22.05
lola22.05, rib35.14/rib[+] has gonadal sheath proper primordium phenotype
lola22.05, rib35.14/rib[+] has gonad | embryonic stage phenotype
lola22.05, rib35.14/rib[+] has germline cell | embryonic stage phenotype
rib35.14/+, lola22.05/+ double heterozygous embryos display a very significant increase in defects in the fusion together and compaction of primordial germ cells and somatic gonadal precursor cells, as compared to controls.
The defects exhibited by rib35.14/rib55.25 transheterozygous embryos to fuse together and compact primordial germ cells and somatic gonadal precursor cells are significantly enhanced by heterozygosity for lola22.05.