FB2024_03 , released June 25, 2024
Allele: Dmel\mysUbi-p63E.Venus
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General Information
Symbol
Dmel\mysUbi-p63E.Venus
Species
D. melanogaster
Name
FlyBase ID
FBal0325621
Feature type
allele
Associated gene
Dmel\mys
Associated Insertion(s)
Carried in Construct
P{Ubi-mys.YFP}
Key Links
Transgenic product class
missense_variant
(Yuan et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Yuan et al., 2010)
Mutagen
in vitro construct
(Yuan et al., 2010)
Progenitor genotype
Carried in construct
P{Ubi-mys.YFP}
Cytology
Description

Ubi-p63E promoter sequences drive expression of mys, which is tagged internally inside a non-conserved, serine-rich region of the 5' section of the hybrid domain with Venus (residues 113-134 are replaced with a non-native Ser and Thr residue followed by the tag).

(Yuan et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
Ubi-p63E
Encoded product / tool
mys
Tagged with
Venus
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      mysUbi-p63E.Venus is a non-suppressor of abnormal locomotor behavior | dominant | adult stage phenotype of MhcS1

      (Pronovost et al., 2013)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The poor climbing ability of MhcS1 heterozygous adults is not suppressed if the flies are also carrying mysUbi-p63E.T:Avic\GFP-YFP.Venus.

      (Pronovost et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      mysUbi-p63E.Venus rescues mys11/mysG1

      (Ellis et al., 2011)

      mysUbi-p63E.Venus rescues mys11

      (Pines et al., 2011)
      Comments

      Approximately 5% of mys11 mutant embryos expressing mysUbi-p63E.T:Avic\GFP-YFP.Venus fail to undergo germband retraction, indicating rescue.

      Expression of mysUbi-p63E.T:Avic\GFP-YFP.Venus rescues the dorsal closure defects seen in mys11 mutant embryos.

      Expression of mysUbi-p63E.T:Avic\GFP-YFP.Venus rescues the myotendinous junction failure seen in mys11 embryos.

      (Pines et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      mysUbi-p63E.T:Avic\GFP-EYFP
      mysUbi-p63E.T:Avic\GFP-YFP.Venus
      mysUbi-p63E.Venus
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0258394
      • FBal0282391
      References (7)