FB2024_03 , released June 25, 2024
Allele: Dmel\PolG1Rescue
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General Information
Symbol
Dmel\PolG1Rescue
Species
D. melanogaster
Name
FlyBase ID
FBal0323341
Feature type
allele
Associated gene
Dmel\PolG1
Associated Insertion(s)
TI{TI}PolG1Rescue
Carried in Construct
Also Known As
Rescue
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
phiC31 integrase
(Bratic et al., 2015)
Progenitor genotype
PolG1KO
(Bratic et al., 2015)
Associated Insertion(s)
TI{TI}PolG1Rescue
Cytology
Description

Wild-type tam at the endogenous locus. Generated by re-integration of DNA into the attP site present in tamKO. Additional sequences inserted during the re-integration event are also present: 1. a loxP cassette containing the wGMR.PHb marker, upstream of tam, 2. a single attR site, downstream of tam.

(Bratic et al., 2015)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      tamRescue/tamRescue flies do not exhibit any obvious phenotype.

      tamRescue/+ flies do not exhibit a significant increase in mtDNA mutation frequency, as compared to wild type.

      tamRescue/tamH1038A and tamRescue/tamD263A mutants do not exhibit a significant difference in mtDNA levels, but offspring of tamRescue/tamD263A mothers exhibit a significant developmental delay.

      (Bratic et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      PolG1Rescue
      Rescue
      (Kauppila et al., 2018, Bratic et al., 2015)
      tamRescue
      Name Synonyms
      Secondary FlyBase IDs
        References (3)