Genomic fragment encompassing the Ank2 locus (derived from BAC clone BACR03I22) in which the endogenous repeat domain of the XL protein isoform (which contains 93 repeat units of 76 amino acid residues) has been replaced by sequence encoding four tandem 5 repeat units.
Expression of Ank2XL-20xR in a Ank2f00518/Ank2f00518 background in larvae results in type 1b axons innervating NMJs exhibit aberrant axonal microtubule accumulations, as compared to controls.
Ank2XL-20xR, Ank2f00518/Ank2f00518 is a suppressor | partially of abnormal neuroanatomy | larval stage phenotype of futschK68
Ank2XL-20xR, Ank2f00518/Ank2f00518 is a suppressor | partially of embryonic/larval neuromuscular junction | larval stage phenotype of futschK68
Ank2XL-20xR, Ank2f00518/Ank2f00518 is a suppressor | partially of microtubule | larval stage phenotype of futschK68
Expression of Ank2XL-20xR in a Ank2f00518/Ank2f00518 mutant background partially rescues the decreased microtubule core filament area seen in futschK68/futschK68 mutant larval neuromuscular junctions.
Ank2XL-20xR partially rescues Ank2f00518
Ank2XL-20xR partially rescues the defective synapse morphology of Ank2f00518/Ank2f00518 mutant larvae.