FB2024_03 , released June 25, 2024
Allele: Dmel\Ank2XL-ΔR
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General Information
Symbol
Dmel\Ank2XL-ΔR
Species
D. melanogaster
Name
FlyBase ID
FBal0322824
Feature type
allele
Associated gene
Dmel\Ank2
Associated Insertion(s)
Carried in Construct
P{Ank2.XL-ΔR}
Key Links
Genomic Maps

Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Stephan et al., 2015)
Progenitor genotype
Carried in construct
P{Ank2.XL-ΔR}
Cytology
Description

Genomic fragment encompassing the Ank2 locus (derived from BAC clone BACR03I22) in which sequence corresponding to the central repeat domain of the the XL protein isoform (amino acid residues 3086-10705) has been deleted. Sequence encoding the L protein isoform is unaffected.

(Stephan et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
Ank2
Encoded product / tool
Ank2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:7,668,939..7,691,796 [-]
Comment:

Genomic fragment corresponding to residues 3086-10705 of annotated isoforms Ank2-PU and Ank2-PAA deleted. Position of deletion endpoints on reference sequence inferred from reported primer sequences.

(Stephan et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Ank2XL-ΔR in a Ank2f00518/Ank2f00518 background in larvae results in type 1b axons innervating NMJs exhibit aberrant axonal microtubule accumulations, as compared to controls.

      (Stephan et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Ank2XL-ΔR in a Ank2f00518/Ank2f00518 mutant background partially rescues the decreased microtubule core filament area seen in futschK68/futschK68 mutant larval neuromuscular junctions.

      (Stephan et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Ank2XL-ΔR partially rescues Ank2f00518

      (Stephan et al., 2015)
      Comments

      Ank2XL-ΔR partially rescues the defective synapse morphology of Ank2f00518/Ank2f00518 mutant larvae.

      (Stephan et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ank2XL-ΔR
      Name Synonyms
      Secondary FlyBase IDs
        References (1)