FlyBase Allele Report: Dmel\Ank2[XL-Δall]

General Information

Symbol

Dmel\Ank2^XL-Δall

Species

D. melanogaster

Name

FlyBase ID

FBal0322820

Feature type

allele

Associated gene

Dmel\Ank2

Associated Insertion(s)

Carried in Construct

P{Ank2.XL-Δall}

Key Links

Genomic Maps

JBrowse

Transgenic product class

wild_type

(Stephan et al., 2015)

Mutagen

Nature of the Allele

Transgenic product class

wild_type

(Stephan et al., 2015)

Mutagen

Progenitor genotype

Carried in construct

P{Ank2.XL-Δall}

Cytology

Description

Genomic fragment encompassing the Ank2 locus (derived from BAC clone BACR03I22) in which all sequence specific to the XL protein isoform (corresponding to residues 2402-11623 of this isoform) has been deleted. This results in loss of expression of the XL protein isoform without affecting expression of the L protein isoform.

(Stephan et al., 2015)

Allele components

Component

Use(s)

Regulatory region(s)

Ank2

Encoded product / tool

Ank2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:7,666,171..7,693,850 [-]

Comment:

Genomic fragment corresponding to residues 2002-11623 of annotated isoforms Ank2-PU and Ank2-PAA deleted. Position of deletion endpoints on reference sequence inferred from reported primer sequences.

(Stephan et al., 2015)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Ank2^f00518

(Stephan et al., 2015)

Phenotype Manifest In

axon | larval stage, with Ank2^f00518

(Stephan et al., 2015)

embryonic/larval neuromuscular junction | larval stage, with Ank2^f00518

(Stephan et al., 2015)

microtubule | larval stage, with Ank2^f00518

(Stephan et al., 2015)

synapse | larval stage, with Ank2^f00518

(Stephan et al., 2015)

type Ib motor neuron | larval stage, with Ank2^f00518

(Stephan et al., 2015)

Detailed Description

Statement

Reference

Expression of Ank2^XL-Δall in a Ank2^f00518/Ank2^f00518 background in larvae results in neuromuscular junctions exhibiting defective microtubule organization and synapse morphology, and the type 1b axons innervating NMJs exhibit aberrant axonal microtubule accumulations, as compared to controls.

(Stephan et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Ank2^XL-Δall, Ank2^f00518/Ank2^f00518 is a non-suppressor of abnormal neuroanatomy | larval stage phenotype of futsch^K68

(Stephan et al., 2015)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Ank2^XL-Δall, Ank2^f00518/Ank2^f00518 is a non-suppressor of embryonic/larval neuromuscular junction | larval stage phenotype of futsch^K68

(Stephan et al., 2015)

Ank2^XL-Δall, Ank2^f00518/Ank2^f00518 is a non-suppressor of microtubule | larval stage phenotype of futsch^K68

(Stephan et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Ank2^XL-Δall in a Ank2^f00518/Ank2^f00518 mutant background fails to rescue the decreased microtubule core filament area seen in futsch^K68/futsch^K68 mutant larval neuromuscular junctions.

(Stephan et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Ank2^XL-Δall partially rescues Ank2^f00518

(Stephan et al., 2015)

Comments

Ank2^XL-Δall rescues the lethality of Ank2^f00518/Ank2^f00518 mutant larvae.

(Stephan et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Ank2^XL-Δall

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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