FB2024_03 , released June 25, 2024
Allele: Dmel\stx2
Open Close
General Information
Symbol
Dmel\stx2
Species
D. melanogaster
Name
FlyBase ID
FBal0319949
Feature type
allele
Associated gene
Dmel\stx
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Du et al., 2016)
Mutagen
FLPase
(Du et al., 2016)
Progenitor genotype
PBac{RB}stxe04410
(Du et al., 2016)
P{XP}d03422
(Du et al., 2016)
Caused by aberration
Df(1)stx2
Cytology
Description

Deletion that removes the stuxnet transcription unit. Generated by FLP-mediated recombination between the insertions P{XP}d03422 and PBac{RB}stuxnete04410.

(Du et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Somatic clones of cells homozygous for stuxnet2 display tergite boundary defects in adult flies.

      Adult homozygous stuxnet2 escapers (that die as pharate adults) show homeotic haltere-to-wing as well as metathoracic-to-mesothoracic leg transformations.

      (Du et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      stx2 has lethal - all die during P-stage phenotype, suppressible by Pc15

      (Du et al., 2016)
      Other
      Statement
      Reference

      stx2, trxB11/trx[+] has visible | adult stage phenotype

      (Du et al., 2016)

      Caf1-105[+]/Caf1-10536, stx2 has visible | adult stage phenotype

      (Du et al., 2016)

      brmT362/brm[+], stx2 has visible | adult stage phenotype

      (Du et al., 2016)

      Iswi[+]/Iswi1, stx2 has visible | adult stage phenotype

      (Du et al., 2016)
      Phenotype Manifest In
      Other
      Statement
      Reference

      stx2, trxB11/trx[+] has tergite phenotype

      (Du et al., 2016)

      Caf1-105[+]/Caf1-10536, stx2 has tergite phenotype

      (Du et al., 2016)

      brmT362/brm[+], stx2 has tergite phenotype

      (Du et al., 2016)

      Iswi[+]/Iswi1, stx2 has tergite phenotype

      (Du et al., 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The pupal stage lethality of hemizygous stuxnet2 males is suppressed by combination with Pc15 in heterozygous state.

      Females double heterozygous for stuxnet2 and any of the following alleles: trxB11, Caf1-10536, brmT362 or Iswi1 females display tergite boundary defects that are not observed in stuxnet2 single heterozygote females.

      (Du et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      stuxnet2
      stx2
      (Du et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)