FB2024_03 , released June 25, 2024
Allele: Dmel\Caf1-10536
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General Information
Symbol
Dmel\Caf1-10536
Species
D. melanogaster
Name
FlyBase ID
FBal0291414
Feature type
allele
Associated gene
Dmel\Caf1-105
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Yu et al., 2013)
Mutagen
P-element activity
(Yu et al., 2013)
Progenitor genotype
Caused by aberration
Df(2R)p10536
Cytology
Description

Imprecise excision of the P{EP} element in P{EP}Caf1-105G2212 has resulted in a 2480bp deletion that covers most of the Caf1-105 coding region and part of CG11777.

(Yu et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The majority of Caf1-10536 mutant larvae do not survive longer than 48 hours after egg deposition (AED) and exhibit an apparent developmental delay and small body size when compared with wild type larvae of the same age. A few escapees live longer than 72 hours, but never survive to the pupal stage.

      In contrast to wild type controls, Caf1-10536 mutant clones (generated in a Minute background) show a notched wing phenotype.

      (Yu et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Caf1-105[+]/Caf1-10536 is an enhancer of visible phenotype of N1

      (Yu et al., 2013)
      Other
      Statement
      Reference

      Caf1-105[+]/Caf1-10536, stx2 has visible | adult stage phenotype

      (Du et al., 2016)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Caf1-105[+]/Caf1-10536 is an enhancer of wing phenotype of N1

      (Yu et al., 2013)
      Other
      Statement
      Reference

      Caf1-105[+]/Caf1-10536, stx2 has tergite phenotype

      (Du et al., 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Double heterozygous stuxnet2;Caf1-10536 females display tergite boundary defects that are not observed in stuxnet2 single heterozygote females.

      (Du et al., 2016)

      One copy of Caf1-10536 enhances the penetrance of the notched wing phenotype seen in N1 mutant flies.

      (Yu et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Caf1-10536 is rescued by Caf1-105UAS.Tag:HA/Scer\GAL4da.G32

      (Yu et al., 2013)
      Comments

      Expression of Caf1-105Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4da.G32 completely rescues the phenotypes seen in Caf1-10536 mutants. These flies do not exhibit any detectable defects.

      (Yu et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Caf1-10536
      (Du et al., 2016)
      Caf1-p10536
      (Shi et al., 2021)
      p10536
      (Yu et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)