FB2024_03 , released June 25, 2024
Allele: Dmel\Cep97LL01167
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General Information
Symbol
Dmel\Cep97LL01167
Species
D. melanogaster
Name
FlyBase ID
FBal0319926
Feature type
allele
Associated gene
Dmel\Cep97
Associated Insertion(s)
PBac{SAstopDsRed}Cep97LL01167
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Galletta et al., 2016)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{SAstopDsRed}Cep97LL01167
    Cytology
    Description

    Insertion which should lead to a significant reduction in the production of the longest isoform of Cep97, Cep97-PB, as the inserted PBac{SAstopDsRed} element contains strong splice acceptors followed by stop codons in all three reading frames (in both orientations).

    (Galletta et al., 2016)
    Allele components
    Component
    Use(s)
    Inserted element
    PBac{SAstopDsRed}
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Cep97LL01167 homozygotes as well as Cep97LL01167/Df(3R)ED5177 males display long centriole phenotype in some male germline stem cells in adult testes, the penetrance of the phenotype is higher in Cep97LL01167/Df(3R)ED5177 animals.

        (Galletta et al., 2016)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The long centriole phenotype observed in some male germline stem cells of Cep97LL01167/Df(2L)A1.G adults is strongly enhanced by combination with SAKc06612/Df(3L)Pc-2q, which results in blocking of centrosome duplication and thus all centrioles remaining are 'remnant' centrioles (originally built from maternally deposited protein and inherited by the developing tissues). Almost all of these remnant centrioles are significantly longer than in controls.

        (Galletta et al., 2016)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially rescued by

        Cep97LL01167/Df(2L)A1.G is partially rescued by Cep97Ubi-p63E.EGFP

        (Galletta et al., 2016)

        Cep97LL01167 is partially rescued by Cep97Ubi-p63E.EGFP

        (Galletta et al., 2016)
        Comments

        The long centriole phenotype observed in some male germline stem cells of either Cep97LL01167/Df(2L)A1.G or Cep97LL01167 homozygous adults is partially rescued by expression of Cep97Ubi-p63E.T:Avic\GFP-EGFP.

        (Galletta et al., 2016)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Cep97LL01167
        cep97LL01167
        (Galletta et al., 2016)
        cep97LL
        (Galletta et al., 2016)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)