FlyBase Allele Report: Dmel\Tm2[Δ8-261]

General Information

Symbol

Dmel\Tm2^Δ8-261

Species

D. melanogaster

Name

FlyBase ID

FBal0319429

Feature type

allele

Associated gene

Dmel\Tm2

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Williams et al., 2015)

Progenitor genotype

Cytology

Description

Genomic deletion that begins in the first coding exon of Tm2 and extends past the final coding exon.

(Williams et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell shape | embryonic stage (with Df(3R)BSC741)

(Williams et al., 2015)

female sterile

(Williams et al., 2015)

lethal - all die before end of first instar larval stage | recessive

(McAdow et al., 2022)

some die during embryonic stage | recessive

(McAdow et al., 2022)

Phenotype Manifest In

Detailed Description

Statement

Reference

A subset of Tm2^Δ8-261/Df(3R)BSC741 embryos display some defects in myotube elongation in lateral transverse muscles 1-3 and lateral longitudinal muscle 1; but do not display any significant difference in the size of the dorsal oblique muscle 2 as compared to controls.

Tm2^Δ8-261/Tm2^Δ8-261 female flies do not lay eggs.

(Williams et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Tm2^Δ8-261 has some die during embryonic stage | recessive phenotype, suppressible | partially by Scer\GAL4^Mef2.PU/Hsap\TPM2^UAS.GFP

(McAdow et al., 2022)

Tm2^Δ8-261 has increased mortality during development | recessive phenotype, suppressible | partially by Scer\GAL4^Mef2.PU/Hsap\TPM2^UAS.GFP

(McAdow et al., 2022)

Tm2^Δ8-261 has some die during embryonic stage | recessive phenotype, suppressible | partially by Scer\GAL4^Mef2.PU/Hsap\TPM2^{K49Del.UAS.GFP}

(McAdow et al., 2022)

Tm2^Δ8-261 has increased mortality during development | recessive phenotype, suppressible | partially by Scer\GAL4^Mef2.PU/Hsap\TPM2^{K49Del.UAS.GFP}

(McAdow et al., 2022)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Tm2^Δ8-261 is partially rescued by Tm2^{K49Del.UAS.GFP}/Scer\GAL4^Mef2.PU

(McAdow et al., 2022)

Tm2^Δ8-261 is partially rescued by Scer\GAL4^Mef2.PU/Tm2^UAS.GFP

(McAdow et al., 2022)

Df(3R)BSC741/Tm2^Δ8-261 is partially rescued by Scer\GAL4^{kirre-rP298-G4}/Tm2^{cDNA.UAS.EGFP}

(Williams et al., 2015)

Comments

Expression of Tm2^{cDNA.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^kirre-rP298 leads to partial rescue of the myotube elongation defects of Tm2^Δ8-261/Df(3R)BSC741 mutant embryos, but does not lead to any significant difference in the size of the dorsal oblique muscle 2 as compared to controls.

(Williams et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Tm2^Δ8-261

(McAdow et al., 2022, Williams et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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