FB2024_03 , released June 25, 2024
Allele: Dmel\Klp98AΔ6
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General Information
Symbol
Dmel\Klp98AΔ6
Species
D. melanogaster
Name
FlyBase ID
FBal0318790
Feature type
allele
Associated gene
Dmel\Klp98A
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ZFN
(Derivery et al., 2015)
Progenitor genotype
Cytology
Description

G to C substitution at position 500 of the coding sequence of Klp98A (CG5658-PA) followed by a 6bp deletion. This changes amino acid residue 167 from Gly to Ala and deletes the two following amino acids (Leu Arg). The deletion maps in the L8 loop of the motor domain and does not affect the stability of the protein.

(Derivery et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:27,552,860..27,552,865 [-]
Comment:

6 bp deletion in coding sequence. There is also a single base substitution at position 500 in the coding sequence in the mutant..

(Derivery et al., 2015)
point_mutation
3R:27,552,866..27,552,866 [-]
Nucleotide change:

G27552866C

Reported nucleotide change:

G500C

Amino acid change:

G167A | Klp98A-PA; G167A | Klp98A-PB

Reported amino acid change:

G167A

Comment:

G to C substitution in codon 167 (position 500 of coding sequence). Mutant also contains a 6 bp deletion immediately following the substitution.

(Derivery et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In Klp98AΔ47/Klp98AΔ8 mutants, Sara endosomes move diffusively and central spindle targeting fails during sensory organ precursor division; endosomes are symmetrically dispatched between pIIa and pIIb in Klp98AΔ47/Klp98AΔ6 or Klp98AΔ47/Klp98AΔ8 mutants.

      (Derivery et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Klp98AΔ6
      (Derivery et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)