FB2024_03 , released June 25, 2024
Allele: Dmel\TbcdUAS.cCa
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General Information
Symbol
Dmel\TbcdUAS.cCa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Chen
FlyBase ID
FBal0318774
Feature type
allele
Associated gene
Dmel\Tbcd
Associated Insertion(s)
Carried in Construct
P{UAS-Tbcd.C}
Key Links
Transgenic product class
wild_type
(Chen et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Chen et al., 2016)
Mutagen
in vitro construct
(Chen et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-Tbcd.C}
Cytology
Description

UASt regulates expression of the full-length coding region of TBCD.

(Chen et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Tbcd
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Microtubule aster is missing in around 70% of interphase neuroblasts and during metaphase mitotic spindles are shorter in the central brain of third instar larvae with expression of TBCDScer\UAS.cCa driven by Scer\GAL4insc.PU; bipolar spindles are still assembled in all metaphase neuroblasts and there is some mild neuroblast overgrowth.

      (Chen et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Arl2T30N.Scer\UAS (or Arl2Δ156/+) increases severity of microtubule growth defects (shorter spindles, inability to form bipolar spindle) in the central brain of third instar larvae with expression of TBCDScer\UAS.cCa driven by Scer\GAL4insc.PU. Presence of Arl2Δ156/+ enhances neuroblast overgrowth in third instar larvae with expression of TBCDScer\UAS.cCa driven by Scer\GAL4insc.PU.

      (Chen et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      TBCDScer\UAS.cCa
      TBCDUAS.cCa
      TbcdUAS.cCa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Chen
      Secondary FlyBase IDs
        References (1)