FB2024_03 , released June 25, 2024
Allele: Dmel\mod(mdg4)GS23019
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General Information
Symbol
Dmel\mod(mdg4)GS23019
Species
D. melanogaster
Name
FlyBase ID
FBal0318603
Feature type
allele
Associated gene
Dmel\mod(mdg4)
Associated Insertion(s)
P{GSV7}mod(mdg4)GS23019
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GSV7}mod(mdg4)GS23019
    Cytology
    Description

    Insertion of a P{GSV7} element in one of the common exons of mod(mdg4), such that the ATG sequence of the 5' P-element end of the P{GSV7} element restores the open reading frame of mod(mdg4) with the loss of the first 8 mod(mdg4) amino acids. Scer\UAS sequences present in the inserted P{GSV7} element may drive expression of the resulting synthetic mod(mdg4) open reading frame in the presence of a Scer\GAL4 driver.

    (Savitsky et al., 2016)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GSV7}
    Regulatory region(s)
    UASt
    Also carries
    loxP
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        mod(mdg4)GS23019/mod(mdg4)GS23019 survive until adult stage but have reduced viability and fitness, males are fertile and females are sterile and both show weak homeotic transformations of abdominal segments A6-8: in males s6 (sternite of the sixth segment) has 4-5 bristles, t7 (tergite of the seventh segment) is slightly enlarged and usually bears several bristles; in females s7 bears 7-14 (average 9.5) bristles and often 3 large instead of 2, and t8 occasionally bears a couple of small bristles.

        mod(mdg4)m9/mod(mdg4)GS23019 have pharate adult lethality and homeotic transformations (A6-8): in males s6 has 3-5 bristles, t7 is enlarged and bears several bristles; in females s7 bears 7-14 (average 9.5) bristles and often 3 large bristles instead of 2, and t8 occasionally bears a couple of small bristles.

        (Savitsky et al., 2016)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Though Cp190P1/Cp1903 or mod(mdg4)m9/mod(mdg4)GS23019 flies die as pharate adults with fully formed cuticles, Cp190P1 mod(mdg4)m9/Cp1903 mod(mdg4)GS23019 double mutant flies die as pupae (P5-7).

        CTCFy+1 mod(mdg4)GS23019 / CTCFEY15833 mod(mdg4)m9 show early pupal lethality (stage P1-4), with rare escapers that die at pharate adult stage and show strong homeotic transformations: in males genitalia is rotated by 180[o], s6 has 4-11 (average 9) bristles, display a small cuticle structure with 1-2 bristles interpreted as s7, t7 is well developed, and t8 is well separated from t9 and bears rows of large bristles; in females phenotypes are as in CTCFy+1/CTCFEY15833 but t8 always has rows of large bristles.

        CTCFEY15833/CTCFEY15833 mod(mdg4)GS23019/mod(mdg4)GS23019 double mutants are viable, males are fertile but females have reduced fertility and flies show stronger homeotic transformations of abdominal segments 6-8 than in either single mutant: in males, genitalia is rotated by 90-180[o] (100%), s6 has 4-15 (average 8) bristles, t7 is well developed, t8 is separated from t9 and bears 0-2 bristles; in females, s7 has 10-15 (average 13) bristles and t8 always has a row of bristles.

        (Savitsky et al., 2016)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        mod(mdg4)GS23019
        (Savitsky et al., 2016)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)