FlyBase Allele Report: Dmel\Cp190[3]

General Information

Symbol

Dmel\Cp190³

Species

D. melanogaster

Name

FlyBase ID

FBal0288494

Feature type

allele

Associated gene

Dmel\Cp190

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: Q61term.

(Oliver et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:15,274,336..15,274,336 [-]

Nucleotide change:

C15274336T

Reported nucleotide change:

C368T

Amino acid change:

Q61term | Cp190-PA; Q61term | Cp190-PB

Reported amino acid change:

Q61term

(Oliver et al., 2010)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal segment 1 (with Cp190^En15)

(Savitsky et al., 2016)

abdominal segment 1 (with Cp190^P1)

(Savitsky et al., 2016)

abdominal segment 2 (with Cp190^En15)

(Savitsky et al., 2016)

abdominal segment 2 (with Cp190^P1)

(Savitsky et al., 2016)

tergite (with Cp190^En15)

(Savitsky et al., 2016)

tergite (with Cp190^P1)

(Savitsky et al., 2016)

wing (with Cp190^En15)

(Savitsky et al., 2016)

wing (with Cp190^P1)

(Savitsky et al., 2016)

Detailed Description

Statement

Reference

The majority of Cp190^En15/Cp190³ flies die as pharate adults, with rare (2%) escapers that die shortly after hatching, and pharate adults show homeotic transformation of abdominal segment A1 into A2 (but no transformations in segments A6-A8): held out wings in escapers are often blistered, the shape of t1 (tergite of the first segment) is changed toward t2, t1 bears long bristles, inner support sclerite is absent or rudimentary, s1 (sternite of the first segment) is often visible but without bristles.

(Savitsky et al., 2016)

Cp190³ is homozygous lethal at the pupal stage.

(Oliver et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Cp190^P1/Cp190³, mod(mdg4)^m9/mod(mdg4)^GS23019 has lethal - all die during pupal stage phenotype

(Savitsky et al., 2016)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Though Cp190^P1/Cp190³ or mod(mdg4)^m9/mod(mdg4)^GS23019 flies die as pharate adults with fully formed cuticles, Cp190^P1 mod(mdg4)^m9/Cp190³ mod(mdg4)^GS23019 double mutant flies die as pupae (P5-7).

(Savitsky et al., 2016)

The ct⁶ wing margin phenotype is fully suppressed by Cp190³/Cp190^P1.

(Oliver et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Cp190³ is rescued by Cp190^{Ubi-p63E.mRFP1}

(Oliver et al., 2010)

Cp190³ is rescued by Cp190^{dZnF.Ubi-p63E.GFP}

(Oliver et al., 2010)

Cp190³ is rescued by Cp190^ΔM.Ubi-p63E

(Oliver et al., 2010)

Not rescued by

Cp190³ is not rescued by Cp190^{BTB-D.Ubi-p63E.GFP}

(Oliver et al., 2010)

Cp190³ is not rescued by Cp190^{dBTB.Ubi-p63E.Tag:MYC}

(Oliver et al., 2010)

Cp190³ is not rescued by Cp190^{dBTB.Ubi-p63E.GFP}

(Oliver et al., 2010)

Comments

Expression of Cp190^{Ubi-p63E.T:Disc\RFP-mRFP} fully rescues the lethality of homozygous Cp190³. The rescued flies are healthy and fertile.

Expression of Cp190^{dZnF.Ubi-p63E.T:Avic\GFP} fully rescues the lethality of homozygous Cp190³. The rescued flies are healthy and fertile.

Expression of Cp190^ΔM.Ubi-p63E rescues the lethality of homozygous Cp190³.

Expression of Cp190^{dBTB.Ubi-p63E.T:Hsap\MYC} fails to rescue the lethality of Cp190³.

Expression of Cp190^{dBTB.Ubi-p63E.T:Avic\GFP} fails to rescue the lethality of Cp190³.

Expression of Cp190^{BTB-D.Ubi-p63E.T:Avic\GFP} fails to rescue the lethality of Cp190³.

(Oliver et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CP190³

(Oliver et al., 2010)

Cp190³

(Fedotova et al., 2023, Kahn et al., 2023, Melnikova et al., 2023, Sabirov et al., 2021, Savitsky et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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