FlyBase Allele Report: Dmel\CTCF[9]

General Information

Symbol

Dmel\CTCF⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0318602

Feature type

allele

Associated gene

Dmel\CTCF

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Deletion of at least 1.7kb from the central part of CTCF (the exact breakpoints are not known).

(Savitsky et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

homeotic | pharate adult stage (with CTCF^P35.2)

(Savitsky et al., 2016)

majority die during pharate adult stage (with CTCF^P35.2)

(Savitsky et al., 2016)

partially lethal - majority die (with CTCF^P35.2)

(Savitsky et al., 2016)

Phenotype Manifest In

abdominal segment 6 | pharate adult stage (with CTCF^P35.2)

(Savitsky et al., 2016)

abdominal segment 7 | pharate adult stage (with CTCF^P35.2)

(Savitsky et al., 2016)

abdominal segment 8 | pharate adult stage (with CTCF^P35.2)

(Savitsky et al., 2016)

abdominal sternite bristle | pharate adult stage (with CTCF^P35.2)

(Savitsky et al., 2016)

male genitalia | pharate adult stage (with CTCF^P35.2)

(Savitsky et al., 2016)

sternite | pharate adult stage (with CTCF^P35.2)

(Savitsky et al., 2016)

tergite | pharate adult stage (with CTCF^P35.2)

(Savitsky et al., 2016)

Detailed Description

Statement

Reference

CTCF^P35.2/CTCF⁹ have pharate adult lethality, with rare escapers that eclose but die within 24-48hr, and show homeotic transformations of abdominal segments (A6-8): in males genitalia is rotated by approximately 20-180[o] (90%), s6 (sternite of the sixth segment) has 4-8 (average 6) bristles; in females s7 has 12-16 (average 14) bristles, shape of s7 transformed toward s6 and bristles lose orientation, and t8 has rows of large bristles.

(Savitsky et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

CTCF⁹/CTCF^y+1 is rescued by CTCF^{Ubi-p63E.Tag:StrepII}

(Savitsky et al., 2016)

CTCF⁹ is rescued by CTCF^{Ubi-p63E.Tag:StrepII}

(Savitsky et al., 2016)

Comments

CTCF^{Ubi-p63E.T:Zzzz\StrepII} rescues viability of CTCF^y+1/CTCF⁹ or CTCF⁹/CTCF⁹ flies.

(Savitsky et al., 2016)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CTCF⁹

(Savitsky et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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