FB2024_03 , released June 25, 2024
Allele: Dmel\CarT43
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General Information
Symbol
Dmel\CarT43
Species
D. melanogaster
Name
FlyBase ID
FBal0318493
Feature type
allele
Associated gene
Dmel\CarT
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Stenesen et al., 2015)
Mutagen
CRISPR/Cas9
(Stenesen et al., 2015)
Progenitor genotype
Cytology
Description

56bp deletion, resulting in a frameshift within the first transmembrane domain followed by a premature stop codon within 1bp.

(Stenesen et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:20,729,987..20,730,042 [-]
Comment:

56bp deletion, resulting in a frameshift within the first transmembrane domain followed by a premature stop codon within 1bp.

(Stenesen et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes lack ON and OFF transients in photoreceptors, indicating disrupted visual signal transduction. Phototactic behavior is severely reduced.

      The overall architecture of the retina and lamina of the eye is not altered in homozygotes.

      (Stenesen et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      CarT43 is rescued by CarTUAS.cSa/Scer\GAL4GMR.long

      (Stenesen et al., 2015)

      CarT43 is rescued by CarTUAS.Tag:MYC/Scer\GAL4GMR.long

      (Stenesen et al., 2015)
      Not rescued by

      CarT43 is not rescued by CarTUAS.cSa/Scer\GAL4repo

      (Stenesen et al., 2015)
      Comments

      Scer\GAL4GMR.long-mediated, but not Scer\GAL4repo-mediated expression of CarTUAS.cSa restores ON and OFF photoreceptor transients in CarT43 mutants.

      Scer\GAL4GMR.long-mediated expression of CarTUAS.Tag:MYC restores ON and OFF photoreceptor transients in CarT43 mutants.

      Scer\GAL4GMR.long-mediated expression of CarTUAS.cSa restores normal phototactic behaviour in CarT43 mutants.

      (Stenesen et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CarT43
      (Shekhar et al., 2023)
      carT43
      (Stenesen et al., 2015)
      carT43A
      (Stenesen et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)