Heterozygous adults which have a maternally inherited null mutation of Ube3a show learning defects (significantly reduced performance in a aversive phototaxis suppression assay compared to controls).
Heterozygous larvae which have a maternally inherited null mutation of Ube3a show learning defects (reduced performance in a taste-aversion paradigm).
Homozygous adults have severe defects in the mushroom body, including fused β-lobes and missing or folded α-lobes.
Heterozygous adults which have a maternally inherited null mutation of Ube3a do not show mushroom body defects.
Ube3aunspecified has abnormal learning | dominant | maternal effect phenotype, suppressible by drlUAS.cCa/Scer\GAL4elav.PU
Ube3aunspecified has abnormal learning | dominant | maternal effect | adult stage phenotype, suppressible by Hsap\UBE3AUAS.iso1.cCa/Scer\GAL4elav.PU
Ube3aunspecified has abnormal learning | dominant | maternal effect | larval stage phenotype, suppressible by Hsap\UBE3AUAS.iso1.cCa/Scer\GAL4elav.PU
Ube3aunspecified has abnormal learning | dominant | maternal effect | adult stage phenotype, non-suppressible by Hsap\UBE3AUAS.iso1.cCa/Scer\GAL4Tab2-201Y
Ube3aunspecified has abnormal learning | dominant | maternal effect | adult stage phenotype, non-suppressible by Hsap\UBE3AUAS.iso1.cCa/Scer\GAL4ey-OK107
Expression of drlScer\UAS.cCa under the control of Scer\GAL4elav.PU rescues the learning defects seen in flies which have a maternally inherited null mutation of Ube3a.
Expression of Hsap\UBE3AScer\UAS.iso1.cCa under the control of Scer\GAL4elav.PU rescues the learning defects seen in larvae and adults which have a maternally inherited null mutation of Ube3a.
Expression of Hsap\UBE3AScer\UAS.iso1.cCa under the control of either Scer\GAL4Tab2-201Y or Scer\GAL4ey-OK107 does not rescue the learning defects seen in adults which have a maternally inherited null mutation of Ube3a.
Ube3aunspecified is rescued by Scer\GAL4elav.PU/Ube3aUAS.cWa
Ube3aunspecified is not rescued by Ube3aC941A.UAS/Scer\GAL4elav.PU
Expression of Ube3aScer\UAS.cWa, but not Ube3aC941A.Scer\UAS, under the control of Scer\GAL4elav.PU rescues the learning defects (reduced performance in a aversive phototaxis suppression assay) of adults which have a maternally inherited null mutation of Ube3a.