FlyBase Allele Report: Dmel\slmb[3A1]

General Information

Symbol

Dmel\slmb^3A1

Species

D. melanogaster

Name

FlyBase ID

FBal0304672

Feature type

allele

Associated gene

Dmel\slmb

Associated Insertion(s)

Carried in Construct

Also Known As

3A1

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Menut et al., 2007)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:21,122,226..21,122,226 [-]

Nucleotide change:

G21122226A

Amino acid change:

W193term | slmb-PA; W193term | slmb-PB; W193term | slmb-PC

Reported amino acid change:

W193term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Skwarek et al., 2014)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | pupal stage | recessive | somatic clone

(Meltzer et al., 2019)

Phenotype Manifest In

axon | pupal stage | somatic clone

(Meltzer et al., 2019)

eye disc | somatic clone

(Menut et al., 2007)

gamma Kenyon cell | pupal stage | somatic clone

(Meltzer et al., 2019)

Detailed Description

Statement

Reference

slmb^3A1 homozygous clones exhibit sevre mushroom body gamma neuron pruning defects, which are not observed in heterozygous individuals or in wild-type clones.

(Meltzer et al., 2019)

Mutant eye discs (generated using the eyFLP-cell lethal system) show epithelial disorganisation accompanied by upregulated actin polymerisation and overgrowth.

(Menut et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

slmb^3A1/slmb[+] is an enhancer of abnormal neuroanatomy | adult stage phenotype of CG9003^indel

(Meltzer et al., 2019)

Phenotype Manifest In

Enhancer of

Statement

Reference

slmb^3A1/slmb[+] is an enhancer of gamma Kenyon cell | adult stage phenotype of CG9003^indel

(Meltzer et al., 2019)

slmb^3A1/slmb[+] is an enhancer of axon | adult stage phenotype of CG9003^indel

(Meltzer et al., 2019)

slmb^3A1/slmb[+] is an enhancer of polytene chromosome phenotype of Cap-H2^Z3-0019, glu[+]/glu^k08819

(Buster et al., 2013)

slmb^3A1/slmb[+] is an enhancer of nurse cell phenotype of Cap-H2^Z3-0019, glu[+]/glu^k08819

(Buster et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

CG9003^indel homozygous adults show mushroom body gamma neuron pruning defects, which become more severe in a slmb^3A1 heterozygous background.

(Meltzer et al., 2019)

glu^k08819/+ ; Cap-H2^Z3-0019/+ double heterozygotes show some unpairing of polytene chromosomes in nurse cells. Unpairing is significantly increased if the animals are also heterozygous for slmb^3A1.

(Buster et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

65423

w^*; P{neoFRT}82B slmb^3A1/TM6B, Tb⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

3A1

(Skwarek et al., 2014, Buster et al., 2013)

MENE (3R)-B^3A1

(Menut et al., 2007)

MENE(3R)-B^3A1

slmb3A1

(Meltzer et al., 2019)

slmb^3A1

Name Synonyms

Secondary FlyBase IDs

FBal0219039
FBal0284277

References (4)

Report Sections

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