FB2024_03 , released June 25, 2024
Allele: Dmel\Dysbrv
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General Information
Symbol
Dmel\Dysbrv
Species
D. melanogaster
Name
FlyBase ID
FBal0302483
Feature type
allele
Associated gene
Dmel\Dysb
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Df(3L)BSC416 Dysbrv double heterozygotes have no effect on excitatory junction potential (EJP) amplitude or miniature EJP frequency compared to controls.

        (Mullin et al., 2015)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT Suppressor of
        Statement
        Reference

        Dysbrv/Dysb[+] is a non-suppressor of abnormal neurophysiology | dominant phenotype of Blos1EY06269

        (Mullin et al., 2015)

        Dysbrv/Dysb[+] is a non-suppressor of abnormal neuroanatomy | dominant phenotype of Blos1EY06269

        (Mullin et al., 2015)

        Dysbrv/Dysb[+] is a non-suppressor of abnormal neuroanatomy | dominant phenotype of Blos1ex65

        (Mullin et al., 2015)
        Phenotype Manifest In
        NOT Suppressor of
        Statement
        Reference

        Dysbrv/Dysb[+] is a non-suppressor of NMJ bouton | increased number phenotype of Blos1EY06269

        (Mullin et al., 2015)

        Dysbrv/Dysb[+] is a non-suppressor of NMJ bouton | increased number phenotype of Blos1ex65

        (Mullin et al., 2015)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        One copy of Dysbrv does not suppress the increase in bouton number seen in Blos1ex65/+ NMJs.

        Blos1EY06269 Dysbrv double heterozygotes have no effect on excitatory junction potential (EJP) amplitude or miniature EJP frequency compared to controls. One copy of Dysbrv suppresses the dominant changes in mEJP amplitude and quantal content seen in Blos1EY06269/+ mutant NMJs. The increase in bouton number seen in Blos1EY06269/+ NMJs is not suppressed.

        (Mullin et al., 2015)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Dysbrv
        dysbrv
        (Mullin et al., 2015)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)