Expression of DgScer\UAS.cYa in the muscle under the control of Scer\GAL4Mef2.PU has no effect on viability.
Expression of DgScer\UAS.cYa in the nervous system under the control of any of Scer\GAL4elav.PU, Scer\GAL4insc.PU or Scer\GAL4wor.PU leads to high levels of embryonic lethality.
The brains of larvae expressing DgScer\UAS.cYa under the control of Scer\GAL4insc.PU contain dense cellular masses that overgrow the normal brain contour, protruding above the neural lamina. The majority of mutants die during the larval stages, but a few escapers make it to adulthood. Adult brains also contain lumps, but fewer than are seen in larvae. The lump-like structures are irregular in size and size correlate with level of Dg expression. They 'lumps' are not tumors: asymmetry of cell division and major differentiation processes appear unaffected. This phenotype can be partially rescued by nitric oxide treatment.
Brain clones expressing DgScer\UAS.cYa under the control of Scer\GAL4Act5C.PP do not show any obvious abnormalities at one day after induction, but after 3 days the cells start to aggregate and form three-dimensional masses that begin to separate from the rest of the brain tissue.
Expression of DgScer\UAS.cYa in photoreceptor neurons under the control of either Scer\GAL4GMR.PU or in mir-310 expressing neurons under the control of Scer\GAL4NP4255 results in premature axon termination in the optic lobe.
Expression of DgScer\UAS.cYa in mir-310 expressing neurons under the control of Scer\GAL4NP4255 results in an increase in M-phase neuroblasts compared to controls.