FB2024_03 , released June 25, 2024
Allele: Dmel\MarfUAS.cYa
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General Information
Symbol
Dmel\MarfUAS.cYa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Yun
FlyBase ID
FBal0301082
Feature type
allele
Associated gene
Dmel\Marf
Associated Insertion(s)
Carried in Construct
P{UAS-Marf.Y}
Key Links
Transgenic product class
cDNA
(Yun et al., 2014)
wild_type
(Yun et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Yun et al., 2014)
wild_type
(Yun et al., 2014)
Mutagen
in vitro construct
(Yun et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-Marf.Y}
Cytology
Description

UASt regulatory sequences drive expression of the Marf RE04414 cDNA.

(Yun et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Marf
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of MarfUAS.cYa under the control of Scer\GAL4VGlut-OK371 induces giant mitochondrial spheres in larval motor neuron cell bodies, as compared to controls.

      (El Fissi et al., 2018)

      Expression of MarfScer\UAS.cYa under the control of Scer\GAL4fln.IFM results in defects in the indirect flight muscles: large mitochondrial clumps, broken mitochondrial cristae and muscle cell death are seen.

      (Yun et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of either Mul1Scer\UAS.cYa or parkScer\UAS.cYa.T:Ivir\HA1 suppresses the mitochondrial clumping which is seen in the indirect flight muscles of flies expressing MarfScer\UAS.cYa under the control of Scer\GAL4fln.IFM.

      (Yun et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      MarfScer\UAS.cYa
      MarfUAS.cYa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Yun
      Secondary FlyBase IDs
        References (3)