FB2024_03 , released June 25, 2024
Allele: Dmel\mGluR2b
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General Information
Symbol
Dmel\mGluR2b
Species
D. melanogaster
Name
FlyBase ID
FBal0300872
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dmGluRA2b, Glu-RA2b
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

mGluR2b/mGluR2b mutant males are defective in progressing through the phases of courtship, but do not display any gross defects in locomotor behavior, olfaction or vision, as compared to wild type.

mGluR2b/+ mutant males do not exhibit a significant difference in courtship behavior, progressing through the phases of courtship, or learning-during-training, immediate-recall memory, short-term memory or long-term memory, and do not display any gross defects in locomotor behavior, olfaction or vision, as compared to wild type.

mGluR2b/+ 30-day-old adult males display no learning defects as they demonstrate normal decrease in courtship activity when paired with an mated unreceptive female and their short-term (60 min) memory is not significantly impaired.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Statement
Reference

mGluR2b/mGluR[+] is a non-suppressor of abnormal learning | male | adult stage | progressive phenotype of PsnB3

mGluR2b/mGluR[+] is a non-suppressor of abnormal memory | male | adult stage | progressive phenotype of PsnB3

mGluR2b/mGluR[+] is a non-suppressor of abnormal learning | male | adult stage | progressive phenotype of PsnI2

mGluR2b/mGluR[+] is a non-suppressor of abnormal memory | male | adult stage | progressive phenotype of PsnI2

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The age-onset learning and memory defects (measured in a courtship behavior assay) characteristic for both PsnI2 and PsnB3 heterozygote males are not suppressed by combination with a single copy of the mGluR2b allele.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)