FB2024_03 , released June 25, 2024
Allele: Dmel\Cp110L.Ubi-p63E.mGFP6
Open Close
General Information
Symbol
Dmel\Cp110L.Ubi-p63E.mGFP6
Species
D. melanogaster
Name
FlyBase ID
FBal0294121
Feature type
allele
Associated gene
Dmel\Cp110
Associated Insertion(s)
Carried in Construct
P{Ubi-lCp110-GFP}
Key Links
Transgenic product class
cDNA
(Franz et al., 2013)
wild_type
(Franz et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Franz et al., 2013)
wild_type
(Franz et al., 2013)
Mutagen
in vitro construct
(Franz et al., 2013)
Progenitor genotype
Carried in construct
P{Ubi-lCp110-GFP}
Cytology
Description

The long isoform of Cp110 (corresponding to RE33938) is fused downstream of Ubi-p63E promoter sequences and upstream of mGFP6 coding sequences.

(Franz et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
Ubi-p63E
Encoded product / tool
Cp110
Tagged with
mGFP6
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cp110L.Ubi-p63E.T:Avic\GFP-m6 spermatocytes exhibit wild-type centrioles and cilia/flagella behaviour and are not noticeably uncoordinated.

      Cp110L.Ubi-p63E.T:Avic\GFP-m6-expressing wing disc cell centrioles are significantly shorter (by approximately 20%) than found in wild-type.

      (Franz et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Cp110L.Ubi-p63E.mGFP6 rescues Cp110Δ

      (Franz et al., 2013)
      Comments

      A Cp110L.Ubi-p63E.T:Avic\GFP-m6 background rescues premature centriole mis-segregation during meiosis in Cp110Δ mutants.

      The formation of microtubule protrusions from Cp110Δ centrioles is suppressed by the presence of Cp110L.Ubi-p63E.T:Avic\GFP-m6.

      Expression of Cp110L.Ubi-p63E.T:Avic\GFP-m6 rescues the long centriole phenotype found in Cp110Δ wing disc cells.

      Overexpression of either Cp110L.Ubi-p63E.T:Avic\GFP-m6 significantly reduces the centriole overduplication seen in third instar larval brain cells expressing SAKUbi.P.T:Avic\GFP.

      (Franz et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cp110L.Ubi-p63E.T:Avic\GFP-m6
      Cp110L.Ubi-p63E.mGFP6
      Name Synonyms
      Secondary FlyBase IDs
        References (3)