FB2024_03 , released June 25, 2024
Allele: Dmel\unc80x42
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General Information
Symbol
Dmel\unc80x42
Species
D. melanogaster
Name
FlyBase ID
FBal0293682
Feature type
allele
Associated gene
Dmel\unc80
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Lear et al., 2013)
Progenitor genotype
P{GSV6}GS12792
(Lear et al., 2013)
Cytology
Description

Imprecise excision of the P{GSV6} element in P{GSV6}GS9462. 14bp of the P{GSV6} element are retained but the UAS repeat sequence has been deleted.

(Lear et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      unc80x42 mutant flies exhibit severe defects in anticipatory behaviour and free-running rhythmicity in comparison to wild type flies. Heterozygotes exhibit a subtle decrease in rhythmicity.

      (Lear et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      unc79x25/unc80x42 males do not exhibit significant DD (constant darkness) behavioural rhythmicity defects compared to wild type controls.

      nae04385/+;; unc80x42/+ flies do not exhibit strong behavioural rhythmicity deficits in DD conditions (constant darkness) compared to single heterozygotes.

      Expression of naScer\UAS.cLa under the control of Scer\GAL4tim.PE does not suppress the circadian behaviour defects seen in unc80x42 mutant flies.

      Expression of unc79Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4tim.PE does not suppress the circadian behaviour defects seen in unc80x42 mutant flies.

      (Lear et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      unc80x42 is rescued by Scer\GAL4tim.PE/unc80UAS.Tag:HA

      (Lear et al., 2013)
      Comments

      Expression of unc80Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tim.PE rescues the circadian behaviour defects seen in unc80x42 mutant flies in both DD (constant darkness) and LD (12 hour light: 12 hour dark) conditions.

      Expression of unc80GS12792 under the control of Scer\GAL4tim.PE rescues the circadian behavior defects seen in unc80x42/unc80GS12792 mutant flies.

      (Lear et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      unc80 X42
      (Lear et al., 2013)
      unc80 [x42]
      (Lear et al., 2013)
      unc8042
      (Lear et al., 2013)
      unc80x42
      (Lear et al., 2013)
      unc80[x42]
      (Lear et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)