FB2024_03 , released June 25, 2024
Allele: Dmel\Wnt6KO
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General Information
Symbol
Dmel\Wnt6KO
Species
D. melanogaster
Name
FlyBase ID
FBal0291770
Feature type
allele
Associated gene
Dmel\Wnt6
Associated Insertion(s)
TI{TI}Wnt6KO
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Doumpas et al., 2013)
Mutagen
ends-out gene targeting
(Doumpas et al., 2013)
Progenitor genotype
Associated Insertion(s)
TI{TI}Wnt6KO
Cytology
Description

Deletion of exon 1 of Wnt6.

(Doumpas et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous Wnt6KO flies are viable and fertile and have no obvious defects in wing size. The wing margin appears intact, and there is no obvious planar cell polarity phenotype.

      Homozygous Wnt6KO flies completely lack maxillary palps.

      Expression of Wnt6Scer\UAS.cDa under the control of Scer\GAL4elav.PU rescues maxillary palp formation in Wnt6KO mutants, but the ectopic expression driven by Scer\GAL4elav.PU results in morphological defects, such as small heads and glazed eyes.

      The spacing of chemosensory bristles in Wnt6KO wings tends to be less precisely specified, with reduced average distance and a broader spacing distribution, compared with controls.

      (Doumpas et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Wnt6KO is rescued by Wnt6UAS.cDa/Scer\GAL4elav.PU

      (Doumpas et al., 2013)
      Comments

      Expression of Wnt6Scer\UAS.cDa under the control of Scer\GAL4elav.PU rescues maxillary palp formation in Wnt6KO mutants, but the ectopic expression driven by Scer\GAL4elav.PU results in morphological defects, such as small heads and glazed eyes

      (Doumpas et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Wnt6KO
      (Doumpas et al., 2013)
      Wnt6{KOd}
      (Holzem et al., 2020)
      wnt6KO
      (Gracia-Latorre et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)