Contains a 49bp deletion in an intron just upstream of the transcription start site for the A isoform mRNA.
Homozygous larvae show a neuromuscular junction (NMJ) overgrowth phenotype (both bouton number and branch points per NMJ are increased compared to wild type). The main axonal stalk of the NMJ is broader than normal. Boutons along the main trunk are larger than normal and appear to almost merge with neighbouring boutons. Numerous small satellite boutons branch off the main axis and hyperbudded boutons appear along the length of the NMJ, with hyperbudding of terminal boutons being especially prominent.
Heterozygous larvae show a mild semidominant NMJ phenotype with increased branch points.
The amplitude of evoked excitatory junctional potentials (EJPs) and the amplitude and frequency of spontaneous miniature EJPs recorded from mutant larval muscles is not significantly different from wild type.
Mob2H4-5, trc1/trc[+] has abnormal neuroanatomy | third instar larval stage phenotype
Mob2H4-5, trc1/trc[+] has NMJ bouton | third instar larval stage phenotype
Mob2H4-5, trc1/trc[+] has embryonic/larval neuromuscular junction | third instar larval stage phenotype
trc1/Mob2H4-5 double heterozygous third instar larvae show a neuromuscular junction (NMJ) overgrowth phenotype comparable to that seen in Mob2H4-5 single homozygotes: both bouton number and branch points per NMJ are increased compared to wild type.
wts3-17/Mob2H4-5 double heterozygous third instar larvae do not show a mutant neuromuscular junction phenotype.
