FB2024_03 , released June 25, 2024
Allele: Dmel\Hsp110UAS.cKa
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General Information
Symbol
Dmel\Hsp110UAS.cKa
Species
D. melanogaster
Name
FlyBase ID
FBal0291066
Feature type
allele
Associated gene
Dmel\Hsp110
Associated Insertion(s)
Carried in Construct
P{UAS-Hsp110.K}
Also Known As
UAS-hsc70cb
Key Links
Transgenic product class
cDNA
(Kuo et al., 2013)
wild_type
(Kuo et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Kuo et al., 2013)
wild_type
(Kuo et al., 2013)
Mutagen
in vitro construct
(Kuo et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Hsp110.K}
Cytology
Description

UAS regulatory sequences drive expression of a Hsc70Cb cDNA (EST clone LD32979).

(Kuo et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsp110
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Hsp110UAS.cKa, Scer\GAL4repo.Switch.2301 is a suppressor | partially of short lived | RU486 conditional phenotype of Hsap\HTTQ128.UAS, Scer\GAL4repo.Switch.2301

      (Martin et al., 2021)
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Hsp110UAS.cKa/Scer\GAL4GMR.PF is a non-suppressor of eye phenotype of Hsap\HTTGMR.Q120

      (Kuo et al., 2013)

      Hsp110UAS.cKa/Scer\GAL4GMR.PF is a non-suppressor of rhabdomere phenotype of Hsap\HTTGMR.Q120

      (Kuo et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsc70CbScer\UAS.cKa does not suppress the external eye degeneration seen when Zzzz\CAG127Q.Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PU. The retinal degeneration is also not suppressed.

      Expression of Hsc70CbScer\UAS.cKa suppresses the external eye degeneration phenotype seen when Zzzz\CAG127Q.Scer\UAS.T:Ivir\HA1 and DnaJ-1Scer\UAS.cKb are co-expressed under the control of Scer\GAL4GMR.PU. No pigmentation loss is seen in either young or aged animals and at one day old all seven photoreceptors with normal sized rhabdomeres are detected.

      Expression of Hsc70CbScer\UAS.cKa does not further suppress the external eye degeneration phenotype seen when Zzzz\CAG127Q.Scer\UAS.T:Ivir\HA1 and mrjScer\UAS.T:Zzzz\FLAG are co-expressed under the control of Scer\GAL4GMR.PU.

      Expression of Hsc70CbScer\UAS.cKa under the control of Scer\GAL4GMR.PF has no effect on neural eye degeneration caused by expression of Hsap\HTTGMR.Q120.

      Hsc70CbScer\UAS.cKa suppresses the neural eye degeneration caused by seen when Hsap\HTTGMR.Q120 and DnaJ-1Scer\UAS.cKb are expressed under the control of Scer\GAL4GMR.PF. Essentially normal morphology is seen in the retinas of these flies at 10 days, although some degeneration is seen at 15 days.

      (Kuo et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsc70CbScer\UAS.cKa
      Hsc70CbUAS.cKa
      Hsp110UAS.cKa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)