FB2024_03 , released June 25, 2024
Allele: Dmel\Raf98
Open Close
General Information
Symbol
Dmel\Raf98
Species
D. melanogaster
Name
FlyBase ID
FBal0285341
Feature type
allele
Associated gene
Dmel\Raf
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Heterozygous phl98 flies exhibit a rough eye morphology due to supernumerary cells within each ommatidium. This phenotype can be reduced through the addition of the Hsp90 inhibitor 17-AAG.

        (Salamanca et al., 2011)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Suppressed by
        Statement
        Reference

        Raf98 has eye phenotype, suppressible by Zzzz\aptamerHsf.X8.UAS/Scer\GAL4αTub84B.PL

        (Salamanca et al., 2011)

        Raf98 has ommatidium phenotype, suppressible by Zzzz\aptamerHsf.X8.UAS/Scer\GAL4αTub84B.PL

        (Salamanca et al., 2011)

        Raf98 has eye phenotype, suppressible by Hsp83e6D

        (Salamanca et al., 2011)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The presence of Hsp83e6D reduces the rough eye morphology seen in Raf98 flies.

        (Salamanca et al., 2011)
        Xenogenetic Interactions
        Statement
        Reference

        The addition of Zzzz\aptamerHsf.X8.Scer\UAS to the genetic background of phl98 heterozygotes (under the control of Scer\GAL4αTub84B.PL) results in the strong suppression of the rough eye phenotype that is caused by increased phl98 signaling activity.

        (Salamanca et al., 2011)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Raf98
        RafBT98
        (Salamanca et al., 2011)
        phl98
        Name Synonyms
        Secondary FlyBase IDs
          References (1)